000 01862cam a2200289 a 4500
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008 130327s2011 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aGift
097 _aM.Sc
099 _aCai01.34.M.Sc.2011.Mo.M
100 0 _aMohammed Weam Ahmed
245 1 0 _aModulating the balance between COX2 and PDE5 inhibitory activities of celecoxib analogues by adapting the nature of the core ring and peripheral rings substitution /
_cMohammed Weam Ahmed ; Supervised Ashraf H. Abadi , Raimund Niess
246 1 5 _aتحوير التوازن التثبيطى لعقار السيليكوكسيب لانزيمى الكوكس - 2 والفو سفودايستراز - 5 عن طريق تكييف طبيعة الحلقة الأساسية ومستبدلات الحلقات الطرفية
260 _aCairo :
_bMohammed Weam Ahmed ,
_c2011
300 _a71Leaves :
_bcharts , facsimiles ;
_c30cm
502 _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
520 _aThe identification and characterization of inducible form of cyclooxygenase (COX2) in inflammatory cells in the early 1990s were the start of a race to the development of more selective nonsteroidal anti - inflammatory drugs (NSAIDs) , collectively known as coxibs , with reduced gastric - and nephrotoxicity compared to classical NSAIDs . However , coxibs were reported to increase the incidence of systemic hypertension and thromboembolic complications including myocardial infarction
700 0 _aAshraf Mostafa Abadi ,
_eSupervisor
700 0 _aRaimund Niess ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aFatma
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c42276
_d42276