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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aGift
097 _aM.Sc
099 _aCai01.34.M.Sc.2013.Am.M
100 0 _aAmro Hefnawy Mohamed Hefnawy
245 1 0 _aModulating celecoxib activity towards phosphodiesterase 5 inhibition rather than cyclooxygenase inhibition and evaluating its correlation to anticancer activity /
_cAmro Hefnawy Mohamed Hefnawy ; Supervised Ashraf H. Abadi
246 1 5 _aتحوير نشاط السيليكوكسيب باتجاه تثبيط الفوسفودايستراز ٥ بدلا من انزيمات الأكسدة الحلقية و ارتباط ذلك بالنشاط المضاد للسرطان
260 _aCairo :
_bAmro Hefnawy Mohamed Hefnawy ,
_c2013
300 _a95 Leaves :
_bphotographs ;
_c30cm
502 _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
520 _aSelective COX-2 inhibitors were introduced as safer alternatives to NSAIDs with less gastrointestinal side effects. Celecoxib, Rofecoxib and valdecoxib were the most widely used COX-2 inhibitors. Unfortunately, it was found that the use of selective COX-2 inhibitors is associated with increased cardiovascular risk. By 2011, celecoxib was the only selective COX-2 inhibitors to remain available in the market as it showed better cardiovascular safety
700 0 _aAshraf Mustafa Kamal Hassan Abadi ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c46792
_d46792