000 01426cam a2200265 a 4500
003 EG-GiCUC
005 20250223031030.0
008 140825s2012 ua f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aGift
097 _aM.Sc
099 _aCai01.34.M.Sc.2012.No.S
100 0 _aNorhan Samir Mahfouz
245 1 0 _aSynthesis and pharmacological evaluation of novel N - acyl (phenylpropylamine) analogs as MT₂⁻ selective ligands for melatonin receptors /
_cNorhan Samir Mahfouz ; Supervised Darius P. Zlotos
260 _aCairo :
_bNorhan Samir Mahfouz ,
_c2012
300 _a125 Leaves ;
_c30cm
502 _aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
520 _aPharmacological actions of the neurohormone melatonin are mediated by the activation of the two G - protein coupled receptors MT₁ and MT₂. An accurate characterisation of melatonin receptor - mediated functions requires MT₁ and MT₂⁻ selective ligands while pronounced MT₁ selectivity is still a challenge, many MT₂⁻ selective ligands, exemplified by compound 14c, have been reported, most of them behaving as antagonists
700 0 _aDarius P. Zlotos ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c47017
_d47017