000			02895cam a2200313 a 4500
003			EG-GiCUC
008			141014s2014 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.09.M.Sc.2014.Mo.P
100	0		_aMohamed Abdelaziz Mahmoud Ibrahim
245	1	0	_aPharmacological study of the possible therapeutic effect of certain natural and synthetic drugs in experimentally induced osteoporosis in rat / _cMohamed Abdelaziz Mahmoud Ibrahim ; Supervised Azza M. Agha , Osama Elshabrawy
246	1	5	_aدراسة فارماكولوجية للتاثير الدوائى المحتمل لبعض المواد الطبيعية و المشيدة فى هشاشة العظام المحدثة معمليا فى الجرذان
260			_aCairo : _bMohamed Abdelaziz Mahmoud Ibrahim , _c2014
300			_a120 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
520			_aThe current study investigated the antiosteoporotic effects of linseed and fish oils as natural sources of polyunsaturated fatty acids on ovariectomy-induced osteoporosis as compared to alendronate sodium; a nitrogen containing bisphosphonate in this model of experimental osteoporosis. Rats were rendered osteoporotic through bilateral ovariectomy and kept on AIN-93 modified diet for 20 weeks. Linseed oil (90 and 180 mg/kg, p.o), fish oil (90 and180 mg/kg, p.o), and alendronate sodium (3 mg/kg, p.o) were administered to rats for 8 weeks. Efficacy of tested agents was judged based on the estimation of serum calcium (Ca+2), phosphorus, osteocalcin (OCN), bone alkaline phosphatase (BALP), tartrate resistant acid phosphatase (TRAP), tumor necrosis factor alpha (TNF-Ü), as well as histopathological examination of bone sections. Besides, bone mineral densities (BMD) of femur, tibia, and spine were measured by dual x-ray absorptiometry to evaluate the effect of the tested drugs on calcium deposition in bone. Linseed and fish oils hampered serum levels of Ca+2, OCN, BALP, TRAP, and TNF-Ü after both 4 and 8 weeks of its administration to the osteoporotic rats along with an increment in serum phosphorus and femur, spine, and tibia BMD as compared to alendronate sodium. Linseed oil and to a better extent fish oil possess promising anti-osteoporotic effects comparable to alendronate that might be attributed to their contents of polyunsaturated fatty acids. Hence, it can be recommended to use them in osteoporotic patients
530			_aIssued also as CD
653		4	_aLinseed oil
653		4	_aOsteoporosis
653		4	_aOvariectomy
700	0		_aAzza M. Agha , _eSupervisor
700	0		_aOsama Elshabrawy , _eSupervisor
905			_aAml _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c48041 _d48041