000			02260cam a2200301 a 4500
003			EG-GiCUC
008			141123s2014 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.10.M.Sc.2014.Sa.S
100	0		_aSalwa Magdy Ahmed Eldaly
245	1	0	_aSynthesis of some new heterocyclic compounds from available nitriles with expected biological activity / _cSalwa Magdy Ahmed Eldaly ; Sypervised Fathy M. Abdelrazek
246	1	5	_a"تشييد بعض المركبات غير متجانسة الحلقة الجديدة من نتيريلات متوافرة ذات نشاط بيولوجى متوقع"
260			_aCairo : _bSalwa Magdy Ahmed Eldaly , _c2014
300			_a89 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520			_aThe original work of this thesis includes the study of the reaction of 1- cyanoacetylpyrazole 1 with phenyl isothiocyanate followed by the addition of different halocarbonyl compounds to afford thiazole and oxathiepine derivatives and the reaction of the arylhydrazo derivative of this compound with phenylene-1,4-diamine to give the compounds 13. Refluxing of 13 with hydrazine hydrate afforded aminotriazoles 15. Compound 1 reacts with different arylazo derivatives of aminopyrazoles to afford the corresponding pyrazolo[1,5-a]pyrimidine derivatives. Compound 21 reacted with phenyl isothiocyanate followed by the addition of different halocarbonyl compounds, the N-alkylated derivatives 24 were obtained.The reaction of 1 with 4- aminoacetophenone afforded the cyanoacetamide derivative 26 which underwent different chemical reactions to give arylidines, iminochromenes, di-arylidenes, di- iminochromenes, di-arylazo compounds and di-thiazoles. The antitumor activity of some of the newly synthesized compounds was investigated in vitro besides Molecule rmodeling (using MOE 2008)
530			_aIssued also as CD
653		4	_a1-Cyanoacetylpyr azole
653		4	_aOxathiepines
653		4	_aThiazole
700	0		_aFathy Mohamed Abdelrazek , _eSupervisor
905			_aAml _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c48363 _d48363