000			02227cam a2200325 a 4500
003			EG-GiCUC
008			150221s2014 ua o f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.08.M.Sc.2014.Da.S
100	0		_aDalia Mohamed Sayed Ahmed
245	1	0	_aStability study of the therapeutic BCG- T using lyophilization technique and different stabilizing agents / _cDalia Mohamed Sayed Ahmed ; Supervised Soad Aly Yehia , Aly Fahmy Mohamed , Ibrahim Elsayed Mohamed Hassan
246	1	5	_aدراسة ثبات مستحضر ال بى سى جى العلاجى باستخدام تقنية التجفيد و أنواع مختلفة من المثبتات
260			_aCairo : _bDalia Mohamed Sayed Ahmed , _c2014
300			_a149 P. : _bphotographs ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aBacillus calmette and guerin (BCG) has been commonly known as an anti tuberculosis vaccine since it was first introduced in paris by calmette and Guerin. Later it was discovered as an important immunotherapeutic agent for treatment of superficial bladder cancer. Being a standard care for many types of bladder cancer, it was one of the early cancer vaccines approved by the FDA. Only two internationally freeze dried BCG products are approved for bladder cancer treatment worldwide due to several restrictions in WHO guidelines. Other manufactures can only distribute their BCG products in their local markets as in case of the Egyptian immunotherapeutic liquid BCG- T. The increased demands of the product in Egypt are associated with the increased bladder cancer incidences. Therefore, development of freeze dried formula has become an urgent need to increase vaccine stability
530			_aIssued also as CD
653		4	_aLyophilization technique
653		4	_aStabilizing agents
653		4	_aTherapeutic BCG- T
700	0		_aAly Fahmy Mohamed , _eSupervisor
700	0		_aIbrahim Elsayed Mohamed Hassan , _eSupervisor
700	0		_aSoad Aly Yehia , _eSupervisor
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c49493 _d49493