| 000 | 02610cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 150331s2014 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.18.M.Sc.2014.Ah.D | ||
| 100 | 0 | _aAhmed Atef Fouad Mekky | |
| 245 | 1 | 0 |
_aDesensitization of donor specific resistant positive lymphocyte cross-match by donor specific mesenchymal stem cell transfusion / _cAhmed Atef Fouad Mekky ; Supervised Mohammed Gamal Aldin Saadi , May Abdelmonem Hasab Allah , Mervat Mohammed Saad Elansary |
| 246 | 1 | 5 | _aإزالة التحسس بإنهاء التفاعل التطابقى الإيجابى للخلايا الليمفاوية بخلايا المتبرع الجزعية |
| 260 |
_aCairo : _bAhmed Atef Fouad Mekky , _c2014 |
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| 300 |
_a138 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine | ||
| 520 | _aBackground: Donor specific antibodies (DSA) and a positive cross-match in patients who are sensitized through previous blood transfusions, organ transplantation or pregnancy are an important obstacle in kidney transplantation. , trials of allograft transplantation across the HLA barrier have employed desensitization strategies, including the use of plasmapheresis, intravenous immunoglobulins, anti-B-cell monoclonal antibodies and splenectomy, associated with high-intensity immunosuppressive regimens. These measures have proven only partially successful in preventing or treating humoral rejection in high-risk patients, while causing a significant increase in the risk of severe infectious complications occurring after transplantation. Mesenchymal stem cells (MSCs) have immunomodulatory capacity and are able to suppress allo-specific antibody production in vitro, and may therefore help overcome a positive cross-match in sensitized transplant recipients. Aim of the Work: To evaluate the effect of mesenchymal stem cell transfusion on desensitization of donor specific resistant positive lymphocyte cross-match and /or high titre Panel Reactive Antibody (PRA) | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aDesensitisation protocols | |
| 653 | 4 | _aImmunomodulatory properties | |
| 653 | 4 | _aMesenchymal stem cells | |
| 700 | 0 |
_aMay Abdelmonem Hasab Allah , _eSupervisor |
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| 700 | 0 |
_aMervat Mohammed Saad El Ansary , _eSupervisor |
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| 700 | 0 |
_aMohammed Gamal Aldin Saadi , _eSupervisor |
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| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c50182 _d50182 |
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