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008 150418s2014 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.07.M.Sc.2014.As.R
100 0 _aAsmaa Mohamed Elsaeed
245 1 4 _aThe role of BCL2 and BAK genes in chronic kidney disease and haemodialysis patients /
_cAsmaa Mohamed Elsaeed ; Supervised Hanan Nour Ahamed , Nariman Mohamed Zahran , Samah Mohammed Abdelhamid
246 1 5 _a فى مرضى الكلى المزمن و مرضى الغسيل الكلوى الدموى bc12 ; bak دورجينى
260 _aCairo :
_bAsmaa Mohamed Elsaeed ,
_c2014
300 _a112 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 _aPolymorphonuclear leucocytes are the first line of defence against foreign invaders and constitute the major cell type involved in certain types of acute and chronic inflammatory diseases. The aim of the present study was to investigate the changes in gene expressions of members of BCL2 family; BCL2 and BAK genes by real time PCR and to study whether they were involved in the accelerated neutrophil apoptosis which might be responsible for the recurrent bacterial infections seen in chronic renal disease and hemodialysis patients and to clarify their potential therapeutic benefit. This study was conducted on sixty two subjects. Patients were selected from those admitted to the Nephrology Department and Hemodialysis Unit, Theodor Bilharz Research Institute (TBRI). Patients under study were classified into three groups; CKD patients (group I) kept on conservative treatment with no previous history of dialysis (22cases), ESRD patients (group II) maintained on dialysis therapy, HD (20cases). In addition, twenty healthy individuals served as a control group (group III) were involved
530 _aIssued also as CD
653 4 _aBAK
653 4 _aBCL2
653 4 _aRQ - PCR
700 0 _aHanan Nour Ahamed ,
_eSupervisor
700 0 _aNariman Mohamed Zahran ,
_eSupervisor
700 0 _aSamah Mohammed Abdelhamid ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c50484
_d50484