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008 150421s2014 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.21.M.Sc.2014.Ma.E
100 0 _aMarwa Nageh Abdelraouf Mahmoud
245 1 0 _aEvaluation of the genetic polymorphisms rate of the tumor necrosis factor- alpha gene at positions -238 and -308 in the Egyptian hepatitis c virus patients /
_cMarwa Nageh Abdelraouf Mahmoud ; Supervised M. Akmal Abdelraheim Elghor , Magda Mohmmed Noshy , Hanaa Ahmed Amer
246 1 5 _aتقييم معدل تعدد الاشكال المظهرية لجين عامل النخر الورمى الفا فى الموضعين -832 و -302 فى المرضى المصريين المصابين بالفيروس الكبدى الوبائى سى
260 _aCairo :
_bMarwa Nageh Abdelraouf Mahmoud ,
_c2014
300 _a118 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520 _aTumor necrosis factor-alpha (TNF-Ü) is an important cytokine in generating an immune response against infection with hepatitis C virus (HCV). In HCV infection, the production of inappropriate cytokine levels may contribute to viral persistence. The G {uF0E0} A transition at position -308 and -238 in the TNF-Ü promoter has shown to affect the overall expression and the secretion of TNF-Ü. The aim of this study was to investigate the prevalence of genotypes associated with polymorphisms of TNF-Ü promoter at position -308 and -238 in a group of Egyptian HCV- infected patients compared with healthy uninfected control subjects. In addition, the association between these polymorphisms and the clinical characteristics of the positive HCV patients were investigated. Genotyping was determined by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP) on genomic DNA isolated from 61 HCV patients and 20 healthy uninfected control
530 _aIssued also as CD
653 4 _aHepatitis C virus,
653 4 _aPolymerase chain reaction
653 4 _aTumor necrosis factors- alpha
700 0 _aHanaa Ahmed Amer ,
_eSupervisor
700 0 _aMagda Mohmmed Noshy ,
_eSupervisor
700 0 _aMohamed Akmal Abdelraheim Elghor ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSoheir
_eCataloger
942 _2ddc
_cTH
999 _c50553
_d50553