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003 | EG-GiCUC | ||
005 | 20250223031218.0 | ||
008 | 150421s2014 ua dh f m 000 0 eng d | ||
040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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041 | 0 | _aeng | |
049 | _aDeposite | ||
097 | _aM.Sc | ||
099 | _aCai01.12.21.M.Sc.2014.Ma.E | ||
100 | 0 | _aMarwa Nageh Abdelraouf Mahmoud | |
245 | 1 | 0 |
_aEvaluation of the genetic polymorphisms rate of the tumor necrosis factor- alpha gene at positions -238 and -308 in the Egyptian hepatitis c virus patients / _cMarwa Nageh Abdelraouf Mahmoud ; Supervised M. Akmal Abdelraheim Elghor , Magda Mohmmed Noshy , Hanaa Ahmed Amer |
246 | 1 | 5 | _aتقييم معدل تعدد الاشكال المظهرية لجين عامل النخر الورمى الفا فى الموضعين -832 و -302 فى المرضى المصريين المصابين بالفيروس الكبدى الوبائى سى |
260 |
_aCairo : _bMarwa Nageh Abdelraouf Mahmoud , _c2014 |
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300 |
_a118 P. : _bcharts , facsimiles ; _c25cm |
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502 | _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology | ||
520 | _aTumor necrosis factor-alpha (TNF-Ü) is an important cytokine in generating an immune response against infection with hepatitis C virus (HCV). In HCV infection, the production of inappropriate cytokine levels may contribute to viral persistence. The G {uF0E0} A transition at position -308 and -238 in the TNF-Ü promoter has shown to affect the overall expression and the secretion of TNF-Ü. The aim of this study was to investigate the prevalence of genotypes associated with polymorphisms of TNF-Ü promoter at position -308 and -238 in a group of Egyptian HCV- infected patients compared with healthy uninfected control subjects. In addition, the association between these polymorphisms and the clinical characteristics of the positive HCV patients were investigated. Genotyping was determined by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP) on genomic DNA isolated from 61 HCV patients and 20 healthy uninfected control | ||
530 | _aIssued also as CD | ||
653 | 4 | _aHepatitis C virus, | |
653 | 4 | _aPolymerase chain reaction | |
653 | 4 | _aTumor necrosis factors- alpha | |
700 | 0 |
_aHanaa Ahmed Amer , _eSupervisor |
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700 | 0 |
_aMagda Mohmmed Noshy , _eSupervisor |
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700 | 0 |
_aMohamed Akmal Abdelraheim Elghor , _eSupervisor |
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856 | _uhttp://172.23.153.220/th.pdf | ||
905 |
_aNazla _eRevisor |
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905 |
_aSoheir _eCataloger |
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_2ddc _cTH |
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_c50553 _d50553 |