| 000 | 02480cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031229.0 | ||
| 008 | 150520s2014 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2014.He.E | ||
| 100 | 0 | _aHesham Abdullah Helmy Eleiwa | |
| 245 | 1 | 0 |
_aEvaluation of the therapeutic effect of whey proteins on the hepatotoxicity induced by paracetamol and alcohol Co-administration in rats / _cHesham Abdullah Helmy Eleiwa ; Ezz Eldin Said Eldenshary , Somaia Ahmad Nada , Mohamed Farrag Elyamany |
| 246 | 1 | 5 | _aتقييم بروتينات شرش اللبن لعلاج التسمم الكبدى المحدث بواسطة الباراسيتامول مع الكحول فى جزذان التجارب |
| 260 |
_aCairo : _bHesham Abdullah Helmy Eleiwa , _c2014 |
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| 300 |
_a174 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aHepatotoxicity induced by oral co-administration of paracetamol (APAP) (500 mg / kg) and alcohol (5 ml/ kg ) to each rat for two and four weeks .On the other hand, oral administration of whey protein isolate (WPI), alpha- lactalbumin (Ü-LA) and beta-lactoglobulin (Ý-LG) are used as therapeutic agents, in two dose levels (100 and 200 mg/kg) after induction of hepatotoxicity in both two and four weeks ,then liver tissue and blood sample collected. Oral administrated of APAP (500 mg / kg ) and alcohol (5 ml/ kg ) for two and four weeks increase in serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST). While, oral administration of WPI, Ü-LA and Ý-LG after APAP and alcohol resulted in reduction in serum AST and ALT activities , serum tumor necrosis factor- alpha (TNF- Ü) and hepatic lipid peroxidation marker malondialdehyde (MDA),while increase oxidative stress biomarkers (hepatic reduced glutathione (GSH) and superoxide dismutase (SOD) | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCo-administration | |
| 653 | 4 | _aHepatotoxicity | |
| 653 | 4 | _aParacetamol | |
| 700 | 0 |
_aEzz Eldin Said Eldenshary , _eSupervisor |
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| 700 | 0 |
_aMohamed Farrag Elyamany , _eSupervisor |
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| 700 | 0 |
_aSomaia Ahmad Nada , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c50972 _d50972 |
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