| 000 | 02451cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 150521s2014 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.10.04.Ph.D.2014.Hu.M | ||
| 100 | 0 | _aHuda Omar Abubaker | |
| 245 | 1 | 0 |
_aMolecular and biochemical studies on osteoarthritis in equine/ _cHuda Omar Abubaker ; Supervised Hatim Mohamed Ahmed Elhindi , Said Zaki Mousa , Adel M. Abouelfetouh Elbehairy |
| 246 | 1 | 5 | _aدراسات جزيئية وبيوكيميائية على الالتهاب العظمى المفصلى فى الخيول |
| 260 |
_aCairo : _bHuda Omar Abubaker , _c2014 |
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| 300 |
_a239 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition | ||
| 520 | _aA central feature of the osteoarthritis (OA) involves erosive destruction of the articular cartilage extracellular matrix (ECM) on the surfaces of joints. The resultant loss of joint function makes studies on mechanisms underlying ECM degradation critical for treatment of the disease and prevention of disability. In the present study serum and synovial fluid samples were collected from normal (n=20), Early OA (n=10) and Late OA (n=20) adult male horses attended from surgery clinic, faculty of veterinary medicine Cairo University. The concentrations of total (TGAGs), individual (CS) and non sulphated (HA) glycosaminoglycans, Procollagen IIC-propeptide (PIICP) and Tartarate resistant acid phosphatase(TRAP) activities were estimated in serum and synovial fluid .The activities of different types of matrix metalloproteinases (MMPs) and tissue inhibitor metalloproteinases (TIMPs) in synovial fluid were estimated by Substrate and Reverse zymography respectively and the expression of MMP-13 was determined by Western blot. The allele and genotype frequencies of the Growth differentiation factor 5(GDF5) and Asporin (ASPN) genes were estimated by PCR- SSCP | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aECM | |
| 653 | 4 | _aGAGs | |
| 653 | 4 | _aOsteoarthritis | |
| 700 | 0 |
_aAdel Mohamed Abouelfetouh Elbehairy , _eSupervisor |
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| 700 | 0 |
_aHatim Mohamed Ahmed Elhindi , _eSupervisor |
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| 700 | 0 |
_aSaid Zaki Mousa , _eSupervisor |
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| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c50978 _d50978 |
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