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| 003 | EG-GiCUC | ||
| 008 | 150526s2014 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.07.Ph.D.2014.Wa.D | ||
| 100 | 0 | _aWalaa Abdelfattah Atya Elkak | |
| 245 | 1 | 0 |
_aDifferential effects of monophosphoryl lipid A and cytokine cocktail as maturation stimuli of dendritic cells for immunotherapy / _cWalaa Abdelfattah Atya Elkak ; Supervised Mervat Mohamed Saad Elansary , Mervat Mohamed Wagih Matter , Ayatallah Amir Nassef |
| 246 | 1 | 5 | _aو خليط السيتوكينات كمحفزات لتنشيط الخلايا الشجيرية المستخدمة فى العلاج المناعى A التأثيرات المختلفة للمونوفوسفورايل ليبيد |
| 260 |
_aCairo : _bWalaa Abdelfattah Atya Elkak , _c2014 |
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| 300 |
_a140 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology | ||
| 520 | _aDendritic cells (DCs) are professional antigen-presenting cells, owing to their superior capacity for acquiring and processing antigens for presentation to T cells. Since dendritic cells were identified as master cells in the modulation of the immune response, a lot of effort has been made to bring their potential to the clinical setting. Dendritic cells - based vaccines are considered an attractive tool for cancer immunotherapy that aim to reset a patient{u2019}s immune system and thereby elicit anti-tumor responses in vivo. In general, generation of MDDC (monocyte derived DC) from monocytes is induced in the presence of GM - CSF and IL - 4, and a maturation stimulus is added to the culture. TNF - Ü is the most common cytokine used for activating DC and generating mature MDDC. A chemically modified Lipopoly-saccharide derivative, monophosphoryl lipid A (MPLA), is one of the promising toll like receptor (TLR) ligands. It has been safely used as an adjuvant in various vaccine trials in humans. In our study, we compared the effects of traditional cytokine coktail (TNF alpha + IL - 1Ý) and MPLA as different maturation stimuli on MDDC | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aDC vaccine | |
| 653 | 4 | _aDendritic cells | |
| 653 | 4 | _aImmunotherapy | |
| 700 | 0 |
_aAyatallah Amir Nassef , _eSupervisor |
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| 700 | 0 |
_aMervat Mohamed Saad Elansary , _eSupervisor |
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| 700 | 0 |
_aMervat Mohamed Wagih Matter , _eSupervisor |
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| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c51058 _d51058 |
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