| 000 | 02610cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031233.0 | ||
| 008 | 150531s2014 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.30.M.Sc.2014.Sa.E | ||
| 100 | 0 | _aSafaa Mohammed Abdelwahab | |
| 245 | 1 | 0 |
_aEffect of insulin and phosphodiesterase type - 5 inhibitor (sildenafil) on aromatase level and uterine function in streptozotocin - induced diabetic female rats / _cSafaa Mohammed Abdelwahab ; Supervised Alaa Eldin Amin Afifi , Hanan Abdelaziz Mubarak , Dina Sabry |
| 246 | 1 | 5 | _aتأثير الإنسولين و العقار المثبط لإنزيم فوسفوداى إستريز٥ (السيلدنافيل) على مستوى الأروماتيز و وظائف الرحم فى إناث الفئران المصابة بداء السكرى الناجم عن إعطاء عقار الإستربتوزوتوسين |
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_aCairo : _bSafaa Mohammed Abdelwahab , _c2014 |
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| 300 |
_a141 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology | ||
| 520 | _aType I Diabetes Mellitus (DM) is associated with multiple reproductive abnormalities and hypoestrogenemia. This study aimed to assess the effect of diabetes on aromatase enzyme gene expression in ovarian and uterine tissues, as well as, its effect on the height of uterine contractions. Also, to identify the possible therapeutic effects of insulin and sildenafil on both the aromatase enzyme level and the height of uterine contractions. Fifty female rats divided into five groups, ten for each, Group I: normal control rats, Group II: untreated streptozotocin-induced diabetic rats, Group III: insulin - treated diabetic, Group IV: phosphodiesterase type 5 inhibitor (PDE5i)-sildenafil-treated diabetic rats and group V: Combined PDE5i (sildenafil) and insulin - treated diabetic rats. Fasting glucose, fasting insulin and estrogen were measured in serum. Aromatase enzyme gene expression was measured in both ovarian and uterine tissues. Peak heights of spontaneous uterine contractions were recorded | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAromatase enzyme | |
| 653 | 4 | _aDiabetes | |
| 653 | 4 | _aUterine contraction | |
| 700 | 0 |
_aAlaa Eldin Amin Afifi , _eSupervisor |
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| 700 | 0 |
_aDina Sabry , _eSupervisor |
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| 700 | 0 |
_aHanan Abdelaziz Mubarak , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c51124 _d51124 |
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