| 000 | 02444cam a2200313 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 150623s2014 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2014.Do.E | ||
| 100 | 0 | _aDoaa Hassan Abdelnaby | |
| 245 | 1 | 0 |
_aEffect of natural products on apoptotic changes related to irradiation-induced mucositis in rats / _cDoaa Hassan Abdelnaby ; Supervised Mohamed T. Khayyal , Mona A. Elghazaly |
| 246 | 1 | 5 | _aتأثير المنتجات الطبيعية على التغيرات المبرمجة لموت الخلايا المرتبط بالتهاب الغشاء المخاطي المحدث بالتشعيع في الجرذان |
| 260 |
_aCairo : _bDoaa Hassan Abdelnaby , _c2014 |
||
| 300 |
_a150 P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aIntestinal mucositis is a common adverse effect that occurs in patients undergoing radiotherapy and often constitutes an important treatment limiting factor during therapy. In an effort to find agents that can effectively guard against this side effect, the present study was initiated to investigate the possible role of certain natural products such as aqueous extract of propolis (AEP) and the herbal preparation, STW 5, in this respect. Intestinal mucositis was induced in rats by exposing them to different radiation exposure levels, delivered either as single (acute) doses or as fractionated ones. Rats were treated orally with AEP (450, 650 and 850 mg/kg) or STW 5 (2, 5 and 10 ml/kg) few days before and continued for 2 days after radiation exposure. Twenty four hours later, the rats were sacrificed and segments of the small intestine were examined histologically. Intestinal homogenates and serum samples were used to assess relevant parameters for apoptosis, oxidative stress, and inflammation. Exposure to radiation produced dose-dependent extents of intestinal injury as judged histologically | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aIntestinal mucositis | |
| 653 | 4 | _aIrradiation-induced mucositis | |
| 653 | 4 | _aNatural products | |
| 700 | 0 |
_aMohamed T. Khayyal , _eSupervisor |
|
| 700 | 0 |
_aMona A. Elghazaly , _eSupervisor |
|
| 905 |
_aAml _eCataloger |
||
| 905 |
_aNazla _eRevisor |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c51416 _d51416 |
||