000 02702cam a2200349 a 4500
003 EG-GiCUC
005 20250223031257.0
008 150812s2014 ua h f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.33.Ph.D.2014.Ah.V
100 0 _aAhmed Abdelaaty Mohammed
245 1 0 _aValue of serum and biliary neutrophil gelatinase - associated lipocalin (NGAL) as a diagnostic marker for cholangiocarcinoma /
_cAhmed Abdelaaty Mohammed ; Supervised Eman Medhat Hassan , Mohammed Salah Abdelbary , Hanan Hassan Fouad
246 1 5 _aدور الليبوكـالين المقترن بجيــلاتيناز النيوتروفيــل فى الـدم و السائل المرارى فى تشخيص سرطان القنوات المرارية
260 _aCairo :
_bAhmed Abdelaaty Mohammed ,
_c2014
300 _a164 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine
520 _aCholangiocarcinoma (CCA) is the most frequent biliary malignancy. It is difficult to diagnose owing to its anatomic location, growth patterns and lack of definite diagnostic criteria. Neutrophil gelatinase - associated lipocalin (NGAL), is a glycoprotein, which is found to increase in many cancers including (CCA). Measurement of NGAL in bile and serum of patients with extrahepatic biliary strictures and its evaluation as a diagnostic marker in differentiating the malignant from the benign strictures, as compared to brush cytology and to other known markers CA19-9 and CEA and its correlation with laboratory variables and the stage of the disease. The study is a cross sectional study including 60 patients presented to endoscopic retrograde cholangiopancreatography (ERCP) unit with extrahepatic biliary obstruction for diagnosis and drainage. Brush cytology was taken from the site of stricture, bile and serum samples were collected for measurement of NGAL, according to the results of brush cytology, Patients were grouped as follows: Group A including 29 patients with malignant extrahepatic strictures, Group B 27 patients with benign extrahepatic strictures as 4 patients were excluded due to unsatisfactory cytology sample
530 _aIssued also as CD
653 4 _aBenign biliary lesions
653 4 _aCholangiocarcinom
653 4 _aNGAL
700 0 _aEman Medhat Hassan ,
_eSupervisor
700 0 _aHanan Hassan Fouad ,
_eSupervisor
700 0 _aMohammed Salah Abdelbary ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c51960
_d51960