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003 EG-GiCUC
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008 151013s2014 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.20.Ph.D.2014.Sh.C
100 0 _aShaimaa Shaheen Mohammed
245 1 0 _aCognitive impairment and magnetic resonance diffusion tensor imaging (MRDTI) of the brain in multiple sclerosis /
_cShaimaa Shaheen Mohammed ; Supervised Randa Shawky Deif , Omar Amin Alserafy , Mohammed Eltokhy
246 1 5 _aالاضطرابات المعرفية و الرنين المغناطيسى الانتشارى التواترى للالياف العصبية للمخ فى مرضى التصلب المتناثر
260 _aCairo :
_bShaimaa Shaheen Mohammed ,
_c2014
300 _a274 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurology
520 _aCognitive impairment is a common concomitant of multiple sclerosis (MS) at both the earlier and later stages of the disease. Objective: to study the pattern of cognitive impairment in various types of MS and its correlation to the results of conventional MRI (c MRI) and diffusion tensor MRI (DTMRI) of the brain. Results: a significant difference was found between cases and control in most of cognitive function tests. Significant difference was found between RRMS & SPMS in cognitive function test and DTMRI brain results (for corpus callosum and temporal lobe) being severe in SPMS patients. Significant difference was found between RRMS and SPMS in c MRI results as regards to brain atrophy being severe in SPMS patients. Conclusion: cognitive dysfunction and brain atrophy occurs early in MS. Cognitive dysfunction was more severe in SPMS than in RRMS patients. DTI brain of NAWM was correlated with cognitive dysfunction in MS especially in regions of corpus callosum, temporal & prefrontal lobes
530 _aIssued also as CD
653 4 _aCognitive dysfunction
653 4 _aDiffusion tensor MRI
653 4 _aMultiple sclerosis
700 0 _aMohammed Eltokhy ,
_eSupervisor
700 0 _aOmar Amin Alserafy ,
_eSupervisor
700 0 _aRanda Shawky Deif ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSoheir
_eCataloger
942 _2ddc
_cTH
999 _c52741
_d52741