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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.10.08.M.Sc.2015.No.H
100 0 _aNoha Ali Elsayed Yasin
245 1 0 _aHistological evaluation of the effect of caffeine on some organs of rats /
_cNoha Ali Elsayed Yasin ; Supervised Youssef Y. Shaheen , Mohamed A. S. Elsakhawy , Mostafa Abbas Shalaby
246 1 5 _aتقييم نسيجى لتأثير الكافايين على بعض الأعضاء فى الفئران
260 _aCairo :
_bNoha Ali Elsayed Yasin ,
_c2015
300 _a318 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Histology and Cytology
520 _aThe possibility that caffeine is a C.N.S. stimulant has neuroendocrinological effect on the pituitary, adrenal and thyroid gland on a short- & long- term consumption has been studied. 91 male adult Sprage - Dawely rats (200-250 gm.) were used & divided into groups: control group and caffeinated group that were injected I/P with different doses of caffeine (5, 50 (ED50) and 100 mg/kg b. wt.) for short-term period (2hr, 4hr and 24hr) and long-term period (1 month). Specimens of glands were collected and processed for histological, histochemical, ultrastructure study. Blood samples were collected for physiological analysis of T3, T4 and corticosterone. Examination of control group and groups receiving caffeine at dose level 5 mg/kg b. wt. for a short period revealed no significance changes in the histological architecture of the glands while groups that receiving 50 &100 mg/kg b. wt. caffeine for a short term showed hyperplasia and hypertrophy of the adenohypophyseal cells but after long term consumption the basophils became enlarged, pale stained and showed degranulation with prominent negative Golgi image while acidophils showed prominent hyperplasia degree of activity
530 _aIssued also as CD
653 4 _aAcidophils
653 4 _aBasophils
653 4 _aCaffeine
700 0 _aMohamed A. S. Elsakhawy ,
_eSupervisor
700 0 _aMostafa Abbas Shalaby ,
_eSupervisor
700 0 _aYoussef Y. Shaheen ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c52759
_d52759