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003 EG-GiCUC
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008 151021s2015 ua h f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.08.09.Ph.D.2015.Ra.P
100 0 _aRasha Refaat Abdelaziz Rashed
245 1 0 _aPossible protective effect of low-dose gamma irradiation and certain natural products on chemically induced hepatotoxicity in rats /
_cRasha Refaat Abdelaziz Rashed ; Supervised Sanaa A. Kenawy , Mona A. Elghazaly
246 1 5 _aالتاثير المحتمل لجرعات التشعيع المنخفضة وبعض المنتجات الطبيعية فى الوقاية من الاعتلال الكبدى المحدث كيميائيا فى الجرذان
260 _aCairo :
_bRasha Refaat Abdelaziz Rashed ,
_c2015
300 _a151 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
520 _aThis study was constructed in order to investigate the hepatoprotective effects offered by each of garlic oil (GO), black seed oil (BO) and sesame oil (SO) each alone or combined with low dose total body gamma (Þ)-irradiation against APAP-induced hepatotoxicity in male albino Wistar rats. To carry out the main study, 96 rats were randomly classified into 2 batches, one of which was subjected to irradiation and the other was kept non-irradiated. The non-irradiated batch was further subclassified into 6 groups. One group served as a normal group, the second group received APAP p.o (1 g/kg). The third, fourth and fifth groups were given either GO (100 mg/kg/day), BO (5 ml/kg/day) or SO (4 ml/kg/day) respectively, orally for 14 days before the induction of hepatotoxicity by APAP. The sixth group received N-acetyl cysteine (NAC, 0.39 g/kg) which was used as a reference hepatoprotective drug. The batch subjected to radiation was further subclassified into six groups. The first group was irradiated at a dose of 0.5 Gy
530 _aIssued also as CD
653 4 _aGamma irradiation
653 4 _aInduced hepatotoxicity
653 4 _aNatural products
700 0 _aMona A. Elghazaly ,
_eSupervisor
700 0 _aSanaa A. Kenawy ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c52849
_d52849