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008 151103s2015 ua f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.10.15.Ph.D.2015.Ha.P
100 0 _aHassan Ahmed Mohamed Shaheen
245 1 0 _aPharmacokinetics of cefquinome in healthy and pasteurella multocida infected rabbits following oral and intramuscular administration and Its interaction with flunixin meglumine /
_cHassan Ahmed Mohamed Shaheen ; Supervised Mostafa Abbas Shalaby , Ayman Goudah Mostafa , Gehan Mohamed Kamel
246 1 5 _aالمسارالحركي لدواء سيفوكينوم فى الأرانب السليمة والمصابة بميكروب الباستريلا ملتوسيدا بعد ا{uئإئ٩}عطاء عن طريق الفم والحقن العضلى وتداخله مع فلونوكسين ميجلومين
260 _aCairo :
_bHassan Ahmed Mohamed Shaheen ,
_c2015
300 _a91 P. ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology
520 _aThis study aimed to investigate the serum disposition kinetics of cefquinome, a fourth generation cephalosporin, in rabbits following a single intramuscular (IM) injection and single oral (PO) administration at a dose 10 mg/kg b.wt in healthy and Pasteurella multocida-infected rabbits, using a parallel design single dose study. Interaction of cefquinome with flunixin meglumine was also tested. Serum samples of cefquinome were measured using HPLC-MS/MS. The results showed that Serum cefquinome disposition kinetic was best fitted to a two-compartment open model after IM and PO dosage in healthy and Pasteurella multocida-infected rabbits. Following IM, Peaks of cefquinome concentrations (Cmax) were 9.05 ± 0.06 and 8.12 ± 0.11 æg/ml attained at 0.95 ± 0.04 and 1.01 ± 0.08 h (Tmax), respectively. The elimination half-lives were 2.60 ± 0.04 and 2.32 ± 0.06 hrs, respectively. Values of area under the curve were 43.26± 0.69 and 34.69 ± 1.03 {uF06D}g. h/ml, respectively. Mean residence times were 4.12 ± 0.05 and 3.72 ± 0.07 h, respectively. The pharmacokinetic profile of cefquinome displays a good absorption and long elimination half-life in rabbits
530 _aIssued also as CD
653 4 _aCefquinome
653 4 _aHPLC assay
653 4 _aPharmacokinetics
700 0 _aAyman Goudah Mostafa ,
_eSupervisor
700 0 _aGehan Mohamed Kamel ,
_eSupervisor
700 0 _aMostafa Abbas Shalaby ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c53070
_d53070