| 000 | 02784cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031329.0 | ||
| 008 | 151103s2015 ua f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.10.15.Ph.D.2015.Ha.P | ||
| 100 | 0 | _aHassan Ahmed Mohamed Shaheen | |
| 245 | 1 | 0 |
_aPharmacokinetics of cefquinome in healthy and pasteurella multocida infected rabbits following oral and intramuscular administration and Its interaction with flunixin meglumine / _cHassan Ahmed Mohamed Shaheen ; Supervised Mostafa Abbas Shalaby , Ayman Goudah Mostafa , Gehan Mohamed Kamel |
| 246 | 1 | 5 | _aالمسارالحركي لدواء سيفوكينوم فى الأرانب السليمة والمصابة بميكروب الباستريلا ملتوسيدا بعد ا{uئإئ٩}عطاء عن طريق الفم والحقن العضلى وتداخله مع فلونوكسين ميجلومين |
| 260 |
_aCairo : _bHassan Ahmed Mohamed Shaheen , _c2015 |
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| 300 |
_a91 P. ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology | ||
| 520 | _aThis study aimed to investigate the serum disposition kinetics of cefquinome, a fourth generation cephalosporin, in rabbits following a single intramuscular (IM) injection and single oral (PO) administration at a dose 10 mg/kg b.wt in healthy and Pasteurella multocida-infected rabbits, using a parallel design single dose study. Interaction of cefquinome with flunixin meglumine was also tested. Serum samples of cefquinome were measured using HPLC-MS/MS. The results showed that Serum cefquinome disposition kinetic was best fitted to a two-compartment open model after IM and PO dosage in healthy and Pasteurella multocida-infected rabbits. Following IM, Peaks of cefquinome concentrations (Cmax) were 9.05 ± 0.06 and 8.12 ± 0.11 æg/ml attained at 0.95 ± 0.04 and 1.01 ± 0.08 h (Tmax), respectively. The elimination half-lives were 2.60 ± 0.04 and 2.32 ± 0.06 hrs, respectively. Values of area under the curve were 43.26± 0.69 and 34.69 ± 1.03 {uF06D}g. h/ml, respectively. Mean residence times were 4.12 ± 0.05 and 3.72 ± 0.07 h, respectively. The pharmacokinetic profile of cefquinome displays a good absorption and long elimination half-life in rabbits | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCefquinome | |
| 653 | 4 | _aHPLC assay | |
| 653 | 4 | _aPharmacokinetics | |
| 700 | 0 |
_aAyman Goudah Mostafa , _eSupervisor |
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| 700 | 0 |
_aGehan Mohamed Kamel , _eSupervisor |
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| 700 | 0 |
_aMostafa Abbas Shalaby , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAml _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c53070 _d53070 |
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