000 02361cam a2200325 a 4500
003 EG-GiCUC
008 151123s2015 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.28.Ph.D.2015.Ha.M
100 0 _aHala Mohsen Abdulsalam Abdullatif
245 1 2 _aA molecular study of mitochondrial hepatopathies in neonates and infants with liver cell failure /
_cHala Mohsen Abdulsalam Abdullatif ; Supervised Nabil Abdelaziz Mohsen , Hanaa Mostafa Elkaraksy , Rokaya Elsayed Mohsen
246 1 5 _aدراسة جزئية لأمراض المتقدرة (الميتوكوندريا) بالكبد فى حديثى الولادة و الأطفال المصابين بفشل فى الكبد
260 _aCairo :
_bHala Mohsen Abdulsalam Abdullatif ,
_c2015
300 _a134 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520 _aAcute liver failure (ALF) in neonates and infants is a life threatening disease. Systematic evaluation of the etiology of ALF may help in establishing a diagnosis and thus guiding treatment decisions. To identify the etiological diagnosis of acute liver failure in neonates and infants; in addition to determining the frequency of DGUOK related mitochondrial DNA depletion syndromes. A cross sectional study carried out at Cairo university children{u2019}s hospital from January 2013 to December 2014. All neonates and infants who presented with acute liver failure and cholestasis with early onset liver failure were included. Acyclovir and lactose free formula were started after drawing samples for HSV and galactose - 1- phosphate. Investigations were tailored according to the patient{u2019}s condition. Mitochondrial DNA content and its percent of control were measured. Amplification of coding regions in DGUOK gene was done using high resolution melting analysis technique
530 _aIssued also as CD
653 4 _aLiver cell failure
653 4 _aMitochondrial
653 4 _aNeonates
700 0 _aHanaa Mostafa Elkaraksy ,
_eSupervisor
700 0 _aNabil Abdelaziz Mohsen ,
_eSupervisor
700 0 _aRokaya Elsayed Mohsen ,
_eSupervisor
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c53470
_d53470