| 000 | 02488cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031343.0 | ||
| 008 | 151126s2015 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2015.Mu.P | ||
| 100 | 0 | _aMuhammed Abdullatif Saad | |
| 245 | 1 | 4 |
_aThe possible neuroprotective effect of ischemic preconditioning, postconditioning and certain agents in global cerebral ischemia-reperfusion induced in rats / _cMuhammed Abdullatif Saad ; Supervised Amina S. Attia , Sanaa A. Kenawy , Rania M. Abdelsalam |
| 246 | 1 | 5 | _aإحتمال التأثير الوقائي العصبي للتهيئة القبلية والبعدية و بعض المواد في إفتقار الدم الشامل وإعادة التروية في مخ الجرذان |
| 260 |
_aCairo : _bMuhammed Abdullatif Saad , _c2015 |
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| 300 |
_a188 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aIn the present experiments, a study of the possible neuroprotective effects elicited by the cysteinyl leukotriene receptor 1 antagonist, montelukast (0.5 mg/kg, p.o.) and the natural flavonoidal compound, pinocembrin (10 mg/kg, p.o). Furthermore, two non-pharmacological techniques with potential protective actions against different models of ischemia reperfusion injury namely, ischemic preconditioning and ischemic postconditioning were also studied. The following biochemical parameters were estimated; lactate dehydrogenase activity, oxidative stress markers (lipid peroxides, reduced glutathione and nitric oxide), inflammatory markers (myeloperoxidase, nuclear factor kappa-B, tumor necrosis factor-alpha, interleukin-10and interleukin-6), neurotransmitters (glutamate, gamma aminobutyric acid) apoptotic and biomarkers (caspase 3 and cytochrome c) were assessed. Additionally, cerebral infarct sizes as well as histopathological changes were investigated in all groups | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aIschemic preconditioning | |
| 653 | 4 | _aMontelukast | |
| 653 | 4 | _aPinocembrin | |
| 700 | 0 |
_aAmina Salem Attia , _eSupervisor |
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| 700 | 0 |
_aRania Mohsen Abdelsalam , _eSupervisor |
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| 700 | 0 |
_aSanaa Abdelbaky Kenawy , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAml _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c53554 _d53554 |
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