| 000 | 02965cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031345.0 | ||
| 008 | 151130s2015 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.12.02.Ph.D.2015.As.E | ||
| 100 | 0 | _aAsem Metwally Aboshanab Salman | |
| 245 | 1 | 0 |
_aEvaluation of glutathione S-transferase M1 genotype and neopterin as prognostic factors in Ý-thalassemia patients / _cAsem Metwally Abo Shanab Salman ; Supervised Abdelgawad Ali Fahmi , Mohamed Ali Eldosouky , Naglaa Mohamed Kholoussi |
| 246 | 1 | 5 | _aتقييم التركيب الوراثى للجلوتاثيون أس-ترانسفيراز أم1 و نيوبترين كعوامل متابعة في مرضى بيتا-ثلاسيميا |
| 260 |
_aCairo : _bAsem Metwally Aboshanab Salman , _c2015 |
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| 300 |
_a173 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry | ||
| 520 | _aThis work was carried out to investigate the role of Neopterin and GSTM1 polymorphism in prognostic Ý-thalassemia, also to detect the correlation between GSTM1 null genotype and appearance cardiac complications in Ý-thalassemia. Methods: This study was divided to three groups (group I: 20 healthy subjects, group II: 56 Ý-thalassemic patients, group III: 16 Ý-thalassemic patients with cardiac complications). The human neopterin and cytokines were determined by ELISA method, while the measurement of human hs-CRP and Immunoglobulins were performed using nephelometry. GSTM1 genotype was detected by PCR and cardiac complications were determined by Echocardiograph. Results: There were statistically significant increases in Neopterin, IL-6, TNF-Ü, IgA, IgG, IgG subclasses (1, 2, 3 & 4) and hs-CRP levels, but statistically insignificant difference in IL-4 and IgM in Ý- thalassemic patients compared to normal subjects. Results showed no relation between GSTM1 null genotype frequency and Ý-thalassemia or cardiac complications appearance. Also results showed that LV diastolic function was significantly impaired in cases with GSTM1 null genotype in group III. Conclusion: Neopterin can be used as a marker for complications of inflammation and infection in Ý-thalassemia. GSTM1 null genotype frequency has no role in beta-thalassemia or cardiac complication appearance. GSTM1 null genotype has a role in cardiac iron overload and impairing of left ventricular diastolic function | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCytokines | |
| 653 | 4 | _aGSTM1 | |
| 653 | 4 | _aNeopterin | |
| 700 | 0 |
_aAbdelgawad Ali Fahmi , _eSupervisor |
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| 700 | 0 |
_aMohamed Ali Eldosouky , _eSupervisor |
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| 700 | 0 |
_aNaglaa Mohamed Kholouss , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c53631 _d53631 |
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