000			02219cam a2200349 a 4500
003			EG-GiCUC
005			20250223031350.0
008			151208s2015 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.07.M.Sc.2015.Em.I
100	0		_aEman Othman Ebrahim Ali
245	1	0	_aInterleukin-23r gene polymorphism in pediatric Egyptian patients with primary immune thrombocytopenia / _cEman Othman Ebrahim Ali ; Supervised Hala Mohammad Farawela , Shahira Kamal Anis , Mona Kamal Elghamrawy
246	1	5	_aتعدد اشكال جين مستقبل الانترلوكين ٢٣ للاطفال المصريين المصابين بمرض الفرفورة الدموية
260			_aCairo : _bEman Othman Ebrahim Ali , _c2015
300			_a136 P. : _bfacsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology
520			_aImmune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of anti-platelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Aim:The current case-control study aimed at detecting the frequency of IL-23R gene polymorphism in egyptian children with ITP and its possible role as a genetic marker for ITP risk. Materials and Methods: IL-23R gene polymorphism was studied in 50 ITP patients and 100 healthy age and sex matched controls by PCR amplification of the target gene followed by allele specific restriction enzyme digestion (RFLP technique). Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls.
530			_aIssued also as CD
653		4	_aChildhood ITP
653		4	_aIL-23R
653		4	_aPolymorphism
700	0		_aHala Mohammad Farawela , _eSupervisor
700	0		_aMona Kamal Elghamrawy , _eSupervisor
700	0		_aShahira Kamal Anis , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAml _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c53828 _d53828