| 000 | 02629cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031353.0 | ||
| 008 | 151212s2015 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.12.02.M.Sc.2015.Gh.M | ||
| 100 | 0 | _aGhada Mohamed Abdelhaleem Elfeki | |
| 245 | 1 | 0 |
_aMolecular characterization for some single nucleotide polymorphisms in the dipeptidy1 peptidase 1 (DPPI) gene / _cGhada Mohamed Abdelhaleem Elfeki ; Supervised Mohamed A. Badway , Mohamed A. Eldesouky , Andrew F. Walls |
| 246 | 1 | 5 | _aتوصيف جزيئى للطفرات أحادية القاعده النيتروجينيه الموجوده فى الجين المسئول عن انزيم تحلل ثنائى الرابطه البيبتيديه |
| 260 |
_aCairo : _bGhada Mohamed Abdelhaleem Elfeki , _c2015 |
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| 300 |
_a111 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry | ||
| 520 | _a Asthma is caused by immune response to environmental stimuli, an effect in which there is airway remodelling. When individuals come in contact with stimuli, their bronchi become inflamed. The inflammatory response is triggered by a chain reaction initiated by several effector molecules. One of these molecules is cathepsin C (CTSC). A mutation within this gene could provide protection against the inflammatory response. Three hundred forty one families, each with at least two siblings with asthma were genotyped for two CTSC polymorphisms (rs217086 (T153I) AND rs3888798 (I453V)) using high resolution melting curve analysis. Genetic association analysis was analysed using family based association tests (FBAT) and resultant called genotypes were sequenced. DNA sequence data confirmed all variant genotypes. Analysis by FBAT showed no significant association between any polymorphisms and asthma susceptibility or with any of asthma-related phenotypes tested. This study failed to confirm a substantial role of the T153I and I453V, CTSC polymorphisms in the genetic predisposition for atopic asthma in a large UK family-based asthma cohort | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aDPPI | |
| 653 | 4 | _aNucleotide | |
| 653 | 4 | _aPolymorphisms | |
| 700 | 0 |
_aAndrew F. Walls , _eSupervisor |
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| 700 | 0 |
_aMohamed Ahmed Badway , _eSupervisor |
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| 700 | 0 |
_aMohamed Aly Eldesouky , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c53904 _d53904 |
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