000			03367cam a2200325 a 4500
003			EG-GiCUC
008			151213s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2015.At.E
100	0		_aAthar Reda Ibrahim Mohamed
245	1	0	_aEvaluation of cardiac function by tissue doppler echocardiography in adolescents with type 1 diabetes and dyslipidemia / _cAthar Reda Ibrahim Mohamed ; Supervised Mona Mamdouh Hassan , Wael Ahmed Attia , Amany Ibrahim Mohamed
246	1	5	_aتقييم وظيفة عضلة القلب باستخدام الدوبلر النسيجى للقلب فى المراهقين المصابين بمرض السكرى من النوع الأول مع اختلال مستوى الدهون بالدم
260			_aCairo : _bAthar Reda Ibrahim Mohamed , _c2015
300			_a180 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aPatients and Methods: Twenty-five dyslipidemic T1DM and 20 normolipidemic T1DM patients, asymptomatic for Cardiovascular disease underwent echocardiography (Pulsed-wave Doppler and TDI) to assess diastolic function. Results: In comparison to normolipidemic T1DM, dyslipidemic T1DM group, the average age was (14.6 ± 2.273yrs.) with disease duration of (6.68± 2.954 yrs.); the mean HbA1c was 8.08%. The mean serum total cholesterol (TC), LDL were significantly higher (p = 0.015 and 0.014 respectively) while HDL were strongly significant lower (p = 0.001). Waist to hip ratio was significantly higher (p = 0.037). Mitral deceleration time was strongly significant lower (p = 0.005) while Tei index was significantly higher (p = 0.048). In suboptimal glycemic control dyslipidemic T1DM (HbA1c {u2265}7.5), Tricuspid A and RV Á were significantly higher (p = 0.043 and 0.043 respectively) while mitral E/A, tricuspid E/A, LV- Lateral E/É and LV- Septal E/É were significantly lower (p = 0.019, 0.043, 0.022 and 0.029 respectively) when compared to patients with HbA1c < 7.5. Serum TC was significantly positive correlated to RV-Á (p = 0.048, r = 0.4) while was significantly negative correlated to RV-É/Á (p = 0.002, r = {u2212}0.590). Serum LDL was significantly positive correlated to disease duration (p = 0.046, r = 0.40) and LV septal Á (p = 0.049, r = 0.397) while was significantly negative correlated to Tricuspid E/A (p = 0.034 r = {u2212} 0.44), LV septal É/Á (p = 0.024, r = {u2212}0.45) and RV-E/É (p= 0.013, r = {u2212}0.489). Serum triglycerides was significantly negative correlated to FS (p = 0.018, r = {u2212}0.47) in dyslipidemic T1DM group. Conclusion: Dyslipidemia and suboptimal glycemic control (HbA1c {u2265} 7.5) can serve as biomarkers for cardiovascular dysfunction in at risk adolescents with T1DM. TDI parameters are adjunctive tools which may be affected early in the course of macrovascular disease
530			_aIssued also as CD
653		4	_aDiastolic function
653		4	_aDyslipidemia
653		4	_aType 1 diabetes
700	0		_aAmany Ibrahim Mohamed , _eSupervisor
700	0		_aMona Mamdouh Hassan , _eSupervisor
700	0		_aWael Ahmed Attia , _eSupervisor
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c53919 _d53919