000			03706cam a2200313 a 4500
003			EG-GiCUC
008			151216s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.24.03.M.Sc.2015.Sh.P
100	0		_aShaimaa Mohamed Saber Elbasiouny
245	1	0	_aPhotodynamic diagnosis of parathyroid glands using different carriers for delivery of aminolevulinic acid / _cShaimaa Mohamed Saber Elbasiouny ; Supervised Tarek Fahmy Abdelaziz Elwakil , Maha Fadel Mohamed Ali
246	1	5	_aا{uئإؤئ}{uئإ٩٧}{uئإآ٧}{uئإء٧}{uئآئإ}ص ا{uئإؤئ}{uئإآئ}و{uئإ٨آ}{uئإئ٠} ا{uئإؤئ}د {uئآئإ}{uئإإ٧}{uئإ٨إ}{uئإإ٣}{uئآئإ}{uئإؤآ}{uئإئ٠} {uئإؤئ}{uئإإ٠}{uئإؤ٠}دة ا{uئإؤئ}{uئإ٩ئ}{uئإ٨إ}ر در{uئإؤ٧}{uئآئإ}{uئآءآ} {uئإ٩١}{uئإ٨٨}{uئإآ٣}{uئإ٩٧}{uئإء٧}دام طرق {uئإإ٣}{uئإء٧}{uئإ٩٧}{uئإإ٠}{uئإؤ٤}{uئآءآ} {uئإإ٧}{uئإ٨إ}{uئإؤ٧}{uئإإ٠}{uئآءآ} {uئإؤئ}{uئإء٣}{uئإ٨إ}{uئإإ٣}ض أ{uئإإ٣}{uئآئإ}{uئإإ٧}و {uئإؤئ}{uئإؤ٤}{uئآئإ}و{uئإؤئ}{uئآئإ}{uئإإ٧}{uئآئإ}ك
260			_aCairo : _bShaimaa Mohamed Saber Elbasiouny , _c2015
300			_a108 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Application in Medical and Biological
520			_aDetection of normal and pathologic parathyroid glands often is difficult due to their variability in number and location. The intraoperative identification of parathyroid glands is challenging yet very important, which is one of the main reasons for postoperative hypoparathyroidism. The feasibility and efficacy of fluorescence diagnosis using the photosensitizer aminolevulinic acid (ALA) has already been proven to identify parathyroid glands in experimental settings. Mostly, modifications of ALA aimed at improving its cellular permeability, increased stability in physiologic pH, increased selectivity and limiting side effects are important challenges in order to extend its clinical use. The present study represents ALA in delivery systems such as conventional liposomes and stealth liposomes and study the feasibility and efficacy of these forms for identifying parathyroids in a fluorescence technique and evaluates fluorescence differences between these delivery forms and the free ALA solution used before.ALA loaded conventional liposomal and stealth liposomal samples were prepared and they were characterized for drug encapsulation %, vesicle size, Zeta potential, in vitro drug release profile and thermal analysis. Seventy rats were randomized into seven groups; a peritoneal lavage was performed with either 1.5 or 3.0% ALA solution in free, conventional or stealth liposomal forms, the photosensitization times of each formula was calculated. After surgical exposure of thyroid and parathyroid glands the operative site was examined under wood{u2019}s light, the identified parathyroid glands were observed and confirmed by histological study, different forms and concentrations of ALA were compared through measuring fluorescence intensities of parathyroid glands by spectrometry
530			_aIssued also as CD
653		4	_aAminolevulinic Acid
653		4	_aParathyroid Glands
653		4	_aPhotodynamic Diagnosis
700	0		_aMaha Fadel Mohamed Ali , _eSupervisor
700	0		_aTarek Fahmy Abdelaziz Elwakil , _eSupervisor
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c53980 _d53980