| 000 | 02719cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031359.0 | ||
| 008 | 151226s2015 ua h f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.19.03.Ph.D.2015.Ab.R | ||
| 100 | 0 | _aAbdallah Mohamed Gamil Abdallah | |
| 245 | 1 | 0 |
_aRole of cytokines genes polymorphisms in predicting the outcome of HLA matched sibling bone marrow transplantation / _cAbdallah Mohamed Gamil Abdallah ; Supervised Azza Mahmoud Kamel , Raafat M. Abdelfattah , Gamal Thabet Ali |
| 246 | 1 | 5 | _aالتنوع فى جينات المحركات الخلوية و دورها فى التنبؤ بنتيجة زرع النخاع بين الأشقاء المتماثلين |
| 260 |
_aCairo : _bAbdallah Mohamed Gamil Abdallah , _c2015 |
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| 300 |
_a228 P. : _bfacsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology | ||
| 520 | _aGraft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation (HSCT) and cytokines are recognized as important mediators of GVHD. Polymorphisms in the regulatory regions of several cytokine genes have been associated with a number of immune diseases as well as post HSCT complications. The aim of this study was the detection of cytokines genes polymorphisms (CGPs) and their relation to post HSCT complications mainly GVHD in Egyptian patients receiving HSCT. The study included 106 patient/donor pairs who received peripheral blood stem cell transplantation (PBSCT) from HLA-matched identical siblings. DNA for cytokine genotyping was available for 105 patients and 98 donors only. Polymerase chain reaction with sequence specific primers (PCR-SSP) technique was used to analyze the following cytokines genotypes: Tumor necrosis factor-alpha (TNF-Ü) ({u2212}308), transforming growth factor beta1 (TGF-Ý1) (codon10 and codon 25), interleukin (IL)-6 ({u2212}174), IL-10 ({u2212}1082, {u2212}819 and {u2212}592) and Interferon {u2013}gamma (IFN-Þ) (+874). From the current study we can conclude that there was no impact of all tested CGPs on development of GVHD or other post HSCT complications. | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAllogeneic HSCT | |
| 653 | 4 | _aGVHD | |
| 653 | 4 | _aPost HSCT complications | |
| 700 | 0 |
_aAzza Mahmoud Kamel , _eSupervisor |
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| 700 | 0 |
_aGamal Thabet Ali , _eSupervisor |
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| 700 | 0 |
_aRaafat Mohamed Abdelfattah , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aSoheir _eCataloger |
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_2ddc _cTH |
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_c54116 _d54116 |
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