000			02269cam a2200337 a 4500
003			EG-GiCUC
005			20250223031403.0
008			160105s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.02.Ph.D.2015.Mo.B
100	0		_aMohamed Abdallah Sayed Ahmed Elweresh
245	1	0	_aBiochemical studies on breast cancer / _cMohamed Abdallah Sayed Ahmed Elweresh ; Supervised Sanaa Osman Abdallah , Abdelfattah Mohamed Attallah
246	1	5	_aدارسات كيميائية حيوية على سرطان الثدى
260			_aCairo : _bMohamed Abdallah Sayed Ahmed Elweresh , _c2015
300			_a176 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
520			_aBreast cancer is considered the leading cause of cancer death among females in economically developing countries. Tumor markers are biochemical indicators for the presence of tumor. The epithelial membrane antigen (EMA) marker could be used to detect small deposits of malignant cells. This work was concerned with the identification and quantitative determination of EMA and then estimating its performance as surrogate marker for identifying breast cancer. Methods: The circulating level of EMA was determined by Western blot and enzyme linked immunosorbent assay (ELISA) in sera from 102 women with Breast cancer and 90 women as controls (40 with benign breast condition and 50 healthy). Results: EMA at 130 kDa was identified. EMA showed area under receiver-operating characteristic curve (AUC) of 0.946 with 69.6% sensitivity, 94.0% specificity, 96.0% PPV, 60.3% NPV, and 77.6% efficiency. Conclusion: EMA may improve the identification of breast carcinoma with a high degree of accuracy in this group of Egyptian women
530			_aIssued also as CD
653		4	_aBreast cancer
653		4	_aGel electrophoresis
653		4	_aWestern blotting
700	0		_aAbdelfattah Mohamed Attallah , _eSupervisor
700	0		_aSanaa Osman Abdallah , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c54273 _d54273