| 000 | 03197cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031405.0 | ||
| 008 | 160110s2015 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.21.Ph.D.2015.Di.S | ||
| 100 | 0 | _aDina Badie Taher Kattaria | |
| 245 | 1 | 0 |
_aStudy of the role of brain-derived neurotrophic factor (BDNF) val66met genetic polymorphism and serum BDNF in the phenotypic expression of mood disorders in a sample of Egyptian patients / _cDina Badie Taher Kattaria ; Supervised Lamis Ali Elray , Mona Yehia Rakhawy , Mohamed Nasreldin Sadek |
| 246 | 1 | 5 | _aفى الأنماط الظاهرية لأمراض اضطرابات المزاج فى عينة من المرضى المصريين (BDNF) و المستوى المصلى للعامل المغذى العصبي الناتج في المخ (VAL66MET) دراسة دور التعدد الجينى |
| 260 |
_aCairo : _bDina Badie Taher Kattaria , _c2015 |
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| 300 |
_a286 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neuro Psychiatry | ||
| 520 | _aBackground: There is substantial evidence that Brain Derived Neurotrophic Factor is involved in the aetiology of mood disorders, however genetic studies assessing the relationship between BDNF and these disorders have produced conflicting results Aim of the study: to investigate the association of BDNF Val66Met polymorphism and serum BDNF with mood disorders per se as well with specific phenotypic aspects in these disorders in a sample of Egyptian patients Methods: A case control study including 62 patients with the diagnoses of bipolar and major depression disorders and 31 controls. The two groups of patients were assessed clinically and were subjected to Hamilton Depression Rating scale, Young Mania Rating scale and Child Traumatic Questionnaire, in addition to the neurocognitive and personality assessment which were administrated to all participants. Serum BDNF levels were determined by using ELISA and Genotyping of Val66Met polymorphism by Real Time Polymerase Chain Reaction(PCR) Results: The serum BDNF level in the control group was found higher than both groups of patients, and this difference was statistically significant between the bipolar group and the control group as well as between the bipolar and the major depression groups of patients .No statistical significant difference between the 3 groups regarding the three genotypes of the Val 66 Polymorphism, but there was a statistical significant difference concerning the relation between the risky genotypes in both groups of patients and certain clinical aspects and some of the Wisconsin indices of the WCST | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBDNF-Serum | |
| 653 | 4 | _aBipolar | |
| 653 | 4 | _aPolymorphism | |
| 700 | 0 |
_aLamis Ali Elray , _eSupervisor |
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| 700 | 0 |
_aMohamed Nasreldin Sadek , _eSupervisor |
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| 700 | 0 |
_aMona Yehia Rakhawy , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aEnas _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c54352 _d54352 |
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