| 000 | 03126cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031409.0 | ||
| 008 | 160116s2015 ua do f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.09.M.Sc.2015.Ka.P | ||
| 100 | 0 | _aKamel Mohamed Kamel | |
| 245 | 1 | 0 |
_aPharmacological study of the possible protective effects of some antioxidants and trace elements on cisplatin-induced nephrotoxicity in rats / _cKamel Mohamed Kamel ; Supervised Mostafa E. Elsayed , Hekma A. Abdellatif , Salwa A. Metwally |
| 246 | 1 | 5 | _aدراسة دوائية للتداخلات المحتملة للتأثيرات الوقائية لبعض مضادات أكسدة و عناصر نادرة علي التسمم الكلوى المحدث بمادة سيسبلاتين في الجرذان |
| 260 |
_aCairo : _bKamel Mohamed Kamel , _c2015 |
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| 300 |
_a243 P. : _bcharts , photographs ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aDrug-induced nephrotoxicity is an extremely common condition and is responsible for a variety of pathological effects on the kidneys. Cisplatin (CIS), one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side-effects, such as nephrotoxicity and ototoxicity. The present study was performed to elucidate some of the mechanisms involved in the nephroprotective effects of selenium, onion oil, hesperidin and rutin in experimentally cisplatin-induced nephrotoxicity in rats. Cisplatin induced nephrotoxicity was confirmed by elevated serum sodium, total sodium and potassium excreted in urine, serum creatinine, urinary creatinine, BUN, urine volume and relative kidney weight and decreased serum potassium and creatinine clearance. Cisplatin also enhanced caused lipid peroxidation manifested as: decrease in the activity of the antioxidant enzyme (SOD), significant depletion of GSH, enhancement of MDA production in the renal tissue and caused degenerative changes, diffuse acute tubular necrosis, focal inflammatory cells infiltration and focal haemorrhage associated with tubular cast formation. Selenium, onion oil, hesperidin or rutin hampered CIS-induced nephrotoxicity manifested by an enhancement of the glomerular filtration rate which was associated by the reduction of serum sodium, total sodium and potassium excreted in urine, serum creatinine, urinary creatinine, BUN, urine volume and relative kidney weight | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCisplatin | |
| 653 | 4 | _aNephrotoxicity | |
| 653 | 4 | _aOxidative stress | |
| 700 | 0 |
_aHekma Abdeltawab Abdellatif , _eSupervisor |
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| 700 | 0 |
_aMostafa Elsayed Elsayed , _eSupervisor |
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| 700 | 0 |
_aSalwa Abdelalla Metwally , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aEnas _eCataloger |
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| 905 |
_aNazla _eRevisor |
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_2ddc _cTH |
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_c54490 _d54490 |
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