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003 EG-GiCUC
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008 160202s2015 ua h f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.10.13.M.Sc.2015.Am.S
100 0 _aAmani Magdi Nagi Mahmoud
245 1 0 _aSimvastatin as a growth promoting material on the healing of critical sized bone defect in dogs:
_bAn experimental study /
_cAmani Magdi Nagi Mahmoud ; Supervised Mohamed Ayad Abdehamid , Elham A. Hassan , Iman Bakr Shaheed
246 1 5 _aالسيمفاستاتين كمادة محفزة للنمو لالتئام النواقص العظمية الحرجة في الكلاب :
_b دراسة تجريبية
260 _aCairo :
_bAmani Magdi Nagi Mahmoud ,
_c2015
300 _a98 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Surgery , Anesthesiology and Radiology
520 _aCritical size defect represents a major challenge in orthopedic surgery. The aim of the work was decided to study the effect of locally applied simvastatin as a growth promoting material on the healing of experimentally induced critical size bone defect in dogs. A prospective experimental study was done on 18 skeletally mature male mongrel dogs. A 21 mm mid-shaft femoral defect was induced in all dogs. Dogs were randomly allocated into one of the two groups; group 1:- simvastatin was locally applied into the defect site, group 2:- defects were kept without simvastatin (sham-operated group). All defect sites were stabilized using bone plate and screws. Dogs were evaluated clinically and radiographically every two weeks till 12 weeks. The dogs were euthanized at 4,8 and 12 weeks for gross pathologic and histopathologic examination (Hematoxyline & Eosin, Masson Trichrome, Alizarine red and immune histochemical evaluation (osteopontin)
530 _aIssued also as CD
653 4 _aCritical sized bone defect
653 4 _aHealing
653 4 _aSimvastatin
700 0 _aElham A. Hassan,
_eSupervisor
700 0 _aIman Bakr Shaheed ,
_eSupervisor
700 0 _aMohamed Ayad Abdelhamid ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c54879
_d54879