000			02540cam a2200313 a 4500
003			EG-GiCUC
008			160225s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.21.Ph.D.2015.So.S
100	0		_aSomaya Hassan Mohammed Khalifa
245	1	2	_aA study to evaluate the protective role of whey protein against alloxan-induced hematological and biochemical alterations in male albino rats / _cSomaya Hassan Mohammed Khalifa ; Supervised Osama Abdelghaffar Youssef, Hayam Abdelrahman Elgazzar
246	1	5	_aدراسة لتقييم الدور الوقائى لبروتين مصل اللبن ضد التغيرات الهيماتولوجية والبيوكيميائية الناجمة عن الألوكسان فى ذكور الجرذان البيضاء
260			_aCairo : _bSomaya Hassan Mohammed Khalifa , _c2015
300			_a236 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology
520			_aThe aim of this study was to evaluate the protective role of the whey protein (WP) against the alloxan-induced oxidative stress and associated metabolic alterations in rats. Eighty male albino rats were divided into four groups: (i) control, (ii) alloxan-injected, (iii) (alloxan+WP)-treated and (iv) WP-administered groups. In the 2nd and 3rd groups, alloxan was intraperitoneally injected at a single dose level of 150 mg/kg b. wt., which is a diabetogenic dose. In the 3rd group, WP was orally administered at a dose level of 3.75 g/kg b. wt. daily for two weeks before alloxan injection and four weeks post-injection. In the 4th group, WP was orally administered to the animals daily for four weeks at dose level of 3.75 g/kg b. wt. From each group, five animals were weekly taken out for sampling of blood and tissues (pancreas and liver). The injection of a single dose of alloxan resulted in a macrocytic hypochromic anemia and leukopenia. Leukopenia was a direct consequence of the reduction in absolute counts of neutrophils and lymphocytes. However, eosinophil, basophil and monocyte counts were not significantly altered
530			_aIssued also as CD
653		4	_aAlloxan
653		4	_aDiabetes mellitus
653		4	_aOxidative stress
700	0		_aHayam Abdelrahman Elgazzar , _eSupervisor
700	0		_aOsama Abdelghaffar Youssef , _eSupervisor
905			_aAml _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c55176 _d55176