000			02957cam a2200325 a 4500
003			EG-GiCUC
008			160225s2015 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.09.M.Sc.2015.Am.P
100	0		_aAmr Moawad Mahmoud
245	1	0	_aPresepsin as index of sepsis severity in correlation with procalcitonin & CRP / _cAmr Moawad Mahmoud ; Supervised Hossam M. Sherif , Khaled M. Taema , Hamdy Saber
246	1	5	_aتقييم مستوي مركب البريسيبسين في الدم في حالات انتان الدم وذلك بالمقارنه بكل من هرمون البروكالسيتونين والبروتين التفاعلي
260			_aCairo : _bAmr Moawad Mahmoud , _c2015
300			_a165 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine
520			_aSepsis is a clinical syndrome that complicates severe infection. It is characterized by the cardinal signs of inflammation (vasodilatation, leukocyte accumulation, increased microvascular permeability) occurring in tissues which are remote from the infection. During the last decade, a variety of different molecules have been suggested as clinical biomarkers in sepsis, most of which are still in experimental stage. However, some have came into use in clinical practice and have evolved as valuable tools for diagnosis, therapy monitoring, and outcome prediction.Early diagnosis is key in successful treatment of sepsis. However, establishing prognosis of sepsis as well as effectiveness of treatment is equally important. Presepsin has been identified as a protein whose levels increase specifically in the blood of sepsis patients. Presepsin is thought to be a more specific and sensitive marker for the diagnosis of sepsis compared with CRP and Procalcitonin (PCT). Presepsin concentrations in blood were increased faster than PCT and CRP in sepsis patients. Although there are a lot of biomarkers to diagnose sepsis, presepsin could be a new candidate for this purpose. In this mini review, we discussed a new biomarker, presepsin, and its clinical relevance The presepsin values were significantly higher in patients with local infection, sepsis, and severe sepsis than in patients who have non infective SIRS. A significant correlation was found between the APACHE II scores, an index of disease severity, and the presepsin values, suggesting that presepsin values can serve as a parameter that closely reflects the pathology
530			_aIssued also as CD
653		4	_aCRP
653		4	_aPresepsin
653		4	_aProcalcitonin
700	0		_aHamdy Mohamed Saber , _eSupervisor
700	0		_aHossam Mostafa Sherif , _eSupervisor
700	0		_aKhaled Mohamed Taema , _eSupervisor
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c55179 _d55179