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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.12.02.Ph.D.2015.Eh.B
100 0 _aEhab Lotfy George Bekhet
245 1 0 _aBiochemical studies on galectin-3 in liver diseases /
_cEhab Lotfy George Bekhet ; Supervised Victorine Beshara Baghous , Abdou Osman Abdelhamid , Nadia Iskandar Zakhary
246 1 5 _aدراسات بيو كيميائية على الجالاكتين-3 فى امراض الكبد
260 _aCairo :
_bEhab Lotfy George Bekhet ,
_c2015
300 _a219 P. :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
520 _aAim: Liver cancer grows silently with mild or no symptoms until the disease is advanced and with little hope of cure. Therefore, the only hope of effective treatment lies in early detection of the disease, or screening for high-risk population. Hepatitis C virus is the most common risk factor of hepatocellular carcinoma (HCC) among Egyptians. The current work was designed to determine the levels of galectin-3 in sera of patients suffering from HCC with different grades and stages, and the most known predisposing diseases; namely hepatitis C virus infection (HCV). Our ultimate goal is to screen for the people who are at high risk to develop HCC especially the patients of HCV and to diagnose it at early stages. Subjects and Methods: the current study was carried out on 75 individuals divided into the following groups: group 1: Normal control (n=12), group 2: HCV (n=29) and group 3: HCC (n=34). Patients were subdivided into cirrhotic and non-cirrhotic in groups 2 and 3. Complete clinic-pathological data were taken for each individual to confirm diagnosis. Sera were subjected to quantitative determinations of different parameters including alpha-fetoprotein (AFP) and galectin-3 (gal-3)
530 _aIssued also as CD
653 4 _aHepatitis B virus
653 4 _aHepatitis C virus
653 4 _aHepatocellular Carcinoma
700 0 _aAbdou Osman Abdelhamid ,
_eSupervisor
700 0 _aNadia Iskandar Zakhary ,
_eSupervisor
700 0 _aVictorine Beshara Baghous ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
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