000 02399cam a2200349 a 4500
003 EG-GiCUC
005 20250223031442.0
008 160316s2015 ua f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.10.M.Sc.2015.Fa.S
100 0 _aFatma Hany Abdelrahman Makroum
245 1 0 _aSerum and tissue 2LIGHT3 levels in patients with multiple or recurrent verruca vulgaris /
_cFatma Hany Abdelrahman Makroum ; Supervised Manal A-W Bosseila , Dina M. Kadry , Olfat G. Shaker
246 1 5 _aمستوى مادة اللايت فى المصل و الجلد للمرضى المصابين بالثآليل الفيروسية المتعددة أو المتكررة
260 _aCairo :
_bFatma Hany Abdelrahman Makroum ,
_c2015
300 _a127 P. ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venereology
520 _aWarts are benign lesions caused by human papilloma virus (HPV). Host defense against HPV relies on intact and functioning cellular immunity including T cell and natural killer (NK) cell cytotoxicity. Therefore, in patients in whom warts are severe or recalcitrant, concern for immune defects is raised. LIGHT (LT - like, exhibits inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) signaling is important for cell survival, inflammation, and tumor eradication. Based on previous studies suggesting a role of LIGHT in control of intracellular infections as M. tuberculosis infection, we hypothesize that LIGHT may contribute to control of HPV infection. To identify the role of cell-mediated immunity, expressed as LIGHT level, in cases of multiple / recurrent verrucae, and to assess whether the immune response is decreased at local level in the skin only, or whether a systemic diminution in cell-mediated immunity is associated in such cases
530 _aIssued also as CD
653 4 _aLIGHT
653 4 _aSerum
653 4 _aTissue
700 0 _aDina Mohamed Kadry ,
_eSupervisor
700 0 _aManal Abdelwahed Bosseila ,
_eSupervisor
700 0 _aOlfat Gamil Shaker ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c55566
_d55566