000			02781cam a2200349 a 4500
003			EG-GiCUC
005			20250223031446.0
008			160324s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.07.M.Sc.2015.Em.I
100	0		_aEmily Samir Mikhael Georgy
245	1	0	_aInterleukin 17-A as an inflammatory marker of multiple organ dysfunction syndrome in patients with major trauma : _bProspective observational study / _cEmily Samir Mikhael Georgy ; Supervised Lamia Mansour , Riham Elessawy , Riham Elsayed
246	1	5	_aإنترلوكين 17- أ كدلالة للالتهاب فى متلازمة الخلل الوظيفي عديد الأعضاء فى مرضى الرضوض الكبرى: _bدراسة استطلاعية
260			_aCairo : _bEmily Samir Mikhael Georgy , _c2015
300			_a92 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520			_aBackground: Multiple organ dysfunction syndrome (MODS) is a systemic, dysfunctional inflammatory response characterized with high mortality rate. The Interleukin-17 (IL-17) family is generally regarded as a bridge system connecting innate and adaptive immunity in induction and mediation of pro-inflammatory responses. Aim of work: The aim of the present study is to investigate association between IL- 17 and MODS in polytrauma patients as well as to test the clinical relevance of IL-17 single nucleotide polymorphism (rs1974226) in patients with major trauma. Results: IL-17 serum level was significantly increased (p=0.039) in group I versus group II patients. As for the IL-17 genotyping, the present study revealed no association (p=0.197) between IL-17 rs1974226 different genotypes and the development of MODS. With regards to mortality, IL-17 serum level was significantly higher (p =0.016) in patients who had a lethal outcome versus those who survived. The ROC curve analysis showed that IL-17 can be a promising biomarker in the prediction of MODS (AUC=0.721) in patients with polytrauma. Conclusion: IL-17 can be considered an important early biochemical marker for predicting the development of MODS. On the other hand, IL-17 rs1974226 might not be associated with the occurrence of MODS
530			_aIssued also as CD
653		4	_aInterleukin-17
653		4	_aMODS
653		4	_aPolytrauma
700	0		_aLamia Mansour , _eSupervisor
700	0		_aRiham Elessawy , _eSupervisor
700	0		_aRiham Elsayed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c55718 _d55718