000			03205cam a2200325 a 4500
003			EG-GiCUC
008			160405s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.18.Ph.D.2015.Ah.P
100	0		_aAhmed Ezzat Ahmed
245	1	0	_aPNPLA3 and TNF genetic polymorphisms in Egyptian patients with Non alcoholic fatty liver disease / _cAhmed Ezzat Ahmed ; Supervised Mona Abdelmonem Hegazy , Laila Ahmed Rashed , Abeer Mostafa Elsayed
246	1	5	_aالأنواع الجينية للبتاتين فوسفوليباز{u٠٦ئ٣} ومعامل التيومر نيكروزيس في المرضى المصريين المصابين بالكبد المتشمع اللاكحولي
260			_aCairo : _bAhmed Ezzat Ahmed , _c2015
300			_a228 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520			_aBackground: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver injury in many countries around the world. The histological changes range over a wide spectrum, extending from simple steatosis, which is generally progressive, to non alcoholic steatohepatitis (NASH) which may progress to liver fibrosis, liver cirrhosis, liver cell failure, and sometimes even hepatocellular carcinoma. Liver biopsy is recommended as a gold standard method for the diagnosis and staging of steatosis and fibrosis, and for detecting inflammation in patients with NAFLD. Patatin like phosphlipase and tumor necrosis factor genes (PNPLA3&TNF) plays a key role in modulating metabolism of hepatic triglycerides and consequently magnitude of NAFLD and progression from simple steatosis to NASH with fibrosis. Objectives: To study the effect of Single nucleotide polymorphisms (SNPs) in PNPLA3, and TNF genes on susceptibility to NAFLD and disease progression. Results: There is a definitive association between heterozygous and the non- wild homozygous polymorphisms of Rs738409 PNPLA3, and Rs361525 TNF genes and NAFLD. In NAFLD patients subgroups; the GG genotype of PNPLA3 gene was higher in NASH patient's subgroup while the AA genotype of Rs361525 TNF gene was higher in patients than controls, but we didn{u2019}t reach any significant results in-between the NAFLD patient's subgroups regarding TNF gene. There were a significant difference between NAFLD patients and normal control participants regarding anthropometric measurements, liver enzymes (ALT, AST and GGT), fasting blood sugar and total lipid profile. Conclusion: There was an association between polymorphisms of the studied SNPs of Rs738409 PNPLA3 gene and Rs361525 TNF gene with the incidence of NAFLD and the severity of the disease
530			_aIssued also as CD
653		4	_aNAFLD
653		4	_aPNPLA3 and TNF genes
653		4	_aSNPs,
700	0		_aAbeer Mostafa Elsayed , _eSupervisor
700	0		_aLaila Ahmed Rashed , _eSupervisor
700	0		_aMona Abdelmonem Hegazy , _eSupervisor
905			_aNazla _eRevisor
905			_aSoheir _eCataloger
942			_2ddc _cTH
999			_c55850 _d55850