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003 EG-GiCUC
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008 160406s2015 ua h f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.10.M.Sc.2015.He.E
100 0 _aHeba Ibrahem Mahmoud Moftah
245 1 0 _aEffect of photochemotherapy on cardiometabolic markers in patients with psoriasis with and without atherosclerosis /
_cHeba Ibrahem Mahmoud Moftah ; Supervised Wedad Zoheir Mostafa , Vanessa Galal Hafez, SaharAbdelatty
246 1 5 _a دراسة تأثير الأشعة فوق البنفسجية (أ) + سورالين على دلالات الأيض والقلب فى مرضى الصدفية المصابين بتصلب الشرايين وغير المصابين بتصلب الشرايين
260 _aCairo :
_bHeba Ibrahem Mahmoud Moftah ,
_c2015
300 _a143 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Dermatology and Venerology
520 _aBackground:Psoriasis is a common chronic systemic inflammatory disease associated with abnormal lipid metabolism, andincreased prevalence of atherosclerosis. Ultraviolet (UV) phototherapy is a well-established therapeutic line for psoriasis. Oxidized LDL (ox-LDL) results from photo-induced oxidative stress. High sensitive C- reactive protein (hs-CRP) isa biomarker of cardiovascular (CVS) risk in addition to other imaging techniques. Objectives: To assess the effect of Psoralen and UV-A (PUVA) on cardiometabolic profile of patients with psoriasis with and without atherosclerosis. Methods:A comparative clinical trial was performed for 17 months, 91patients with chronic plaque psoriasis were examined. Fifty patients fulfilled the criteria for inclusion. Fifteen apparently normal individualswere included as controls.Twenty seven adult patients with psoriasis were put in one of the two arms of the study: with atherosclerosis (high risk) and without atherosclerosis (low risk). Duplex ultrasonography, body mass index (BMI), waist circumference, arterial blood pressure (ABP),high sensitive C reactive protein (hs-CRP), oxidized LDL(ox-LDL), lipid profile and fasting blood sugar (FBS) were assessed before and after 36 sessions of PUVA. Data analysis in the comparative clinical trial included total group analysis and subgroup analysis. Correlations were performed
530 _aIssued also as CD
653 4 _aComparative clinical trial
653 4 _aPsoriasis
653 4 _aPUVA
700 0 _aSahar Abdelatty ,
_eSupervisor
700 0 _aVanessa Galal Hafez ,
_eSupervisor
700 0 _aWedad Zoheir Mostafa ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c55892
_d55892