000			03029cam a2200337 a 4500
003			EG-GiCUC
005			20250223031452.0
008			160407s2015 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.09.M.Sc.2015.No.S
100	0		_aNoha Fawzy Hassan
245	1	2	_aA Study on the possible therapeutic effects of whey protein products against hepatic fibrosis in experimental rats / _cNoha Fawzy Hassan ; Supervised Ezz Eldin Said Eldenshary , Somia A. Nada
246	1	5	_aالدراسات العلاج{u٠٦أأ}ة المحتملة من منتجات مصل بروت{u٠٦أأ}ن اللبن على التل{u٠٦أأ}ف الكبدى فى الجرذان
260			_aCairo : _bNoha Fawzy Hassan , _c2015
300			_a147 P. : _bfacsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
520			_aInflammation and hepatic stellate cell (HSC) activation are the most crucial steps in the formation of hepatic fibrosis. Hepatocytes damaged by viral or bacterial infection, alcohol or toxic chemicals initiate an inflammatory response that activates collagen production by HSCs. Through this mechanism chronic administration of thioacetamide for 8 weeks at dose (100 mg/kg body weight) effectively induced liver injury and dysfunction and caused hepatic fibrosis. In this study, the effect of Betalactglobulin (Ý-LG), Lacprodan R alpha-10(LAC) and L-methionine were evaluated in TAA-induced hepatic fibrosis in rats. Method: Seventy two Sprague Dawley rats were divided into nine groups. Group 1 received saline only; all groups were injected with TAA two times / week, concurrently, Group3-4 received daily Ý-LG (100mg/kg and 200 mg/kg given orally), respectively.Group 5 received a combination of Ý-LG (50 mg/kg body weight) and l-methionine (40 mg/kg body weight).Groups 6,7 and 8were received the same as groups 3,4 and 5 except we use LAC instead of Ý-LG ,while group 9 was received L-methionine (40 mg/kg body weight) only. Results: TAA induced extensive liver damage that is evidenced by significant increase in serum levels of alanine amino transferase (ALT), Aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin(TB) .Moreover, TAA induced oxidative stress as indicated by significant increase in the hepatic lipid peroxidation (LPO)marker malondialdehyde (MDA) and nitric oxide content(NO) as well as significant decrease in antioxidant enzymes like hepatic reduced glutathione concentration (GSH) and superoxide dismutase (SOD) activities
530			_aIssued also as CD
653		4	_aHepatic fibrosis
653		4	_aLacprodan-alpha-10
653		4	_aThioacetamide
700	0		_aEzz Eldin Said Eldenshary , _eSupervisor
700	0		_aSomia Ahmed Nada , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAml _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c55908 _d55908