| 000 | 02741cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 160412s2015 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.01.M.Sc.2015.Mo.P | ||
| 100 | 0 | _aMohamed Rizk Abdelkhalik Rizk | |
| 245 | 1 | 0 |
_aPossible treatment regimens against the hepatotoxic effect of some antitubercular drugs in rats / _cMohamed Rizk Abdelkhalik Rizk ; Supervised Samy Abdelfattah Abdelazim , Rokaya Mahmoud Hussein , Ahmed Abdellatif Badr |
| 246 | 1 | 5 | _aأنظمة علاج محتملة لتخفيف الآثار الكبدية الضارة لبعض الأدوية المستخدمة فى علاج مرضى السل فى الجرذان |
| 260 |
_aCairo : _bMohamed Rizk Abdelkhalik Rizk , _c2015 |
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| 300 |
_a208 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry | ||
| 520 | _aAim: Tuberculosis is a dangerous disease and its death toll is increasing year by year. Intake of isoniazid and rifampicin might lead to fatal hepatorenal toxicity. The emerging field of stem cell therapy has raised great hope for improving the treatment of liver diseases. Results: The study revealed that serum liver enzymes activities, liver and kidney thiobarbituric acid reactive substance and nitric oxide levels, serum lipid profile and DNA fragmentation which exhibited by comet assay were significantly increased by isoniazid and rifampicin treatment associated with marked reduction of serum levels of albumin, total protein and albumin/globulin ratio, as well as liver and kidney glutathione levels and antioxidant enzymes activities, catalase and superoxide dismutase, as compared to normal controls. These results showed that N-acetyl cysteine, mesenchymal stem cells and white tea extract exerts their protective activity by different extents on liver and kidney by inhibiting the production of free radicals through induction of antioxidant enzymes and improving non-enzymatic thiol antioxidant, glutathione, and returning back the tested parameters towards near the normal controls. Furthermore, liver and kidney functions were improved greatly by mesenchymal stem cells followed by N- acetyl cysteine and white tea extract, respectively | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aHepatorenal toxicity | |
| 653 | 4 | _aIsoniazid | |
| 653 | 4 | _aRifampicin | |
| 700 | 0 |
_aAhmed Abdellatif Badr , _eSupervisor |
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| 700 | 0 |
_aRokaya Mahmoud Hussein , _eSupervisor |
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| 700 | 0 |
_aSamy Abdel-Fattah Abdelazim , _eSupervisor |
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| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c55979 _d55979 |
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