000 03700cam a2200337 a 4500
003 EG-GiCUC
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008 160505s2015 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.08.09.M.Sc.2015.Mo.S
100 0 _aMohamed Farouk Ahmed Abdelsalam
245 1 0 _aStudy on possible pharmacological effects of gliclazide alone or in combination with carbamazepine or alpha lipoic acid in experimentally induced diabetic neuropathy in rats /
_cMohamed Farouk Ahmed Abdelsalam ; Supervised Ezz-Eldin S. Eldenshary , Rania M. Abdelsalam
246 1 5 _aدرا{uئإآ٣}{uئإ٩٤} {uئإأآ}{uئإإ٦} ا{uئإء٣}{uئإ٩٨}{uئإإ٤}{uئإ٨إ}{uئإؤئ}{uئآئئ}{uئإ٩٤} {uئإء٣}{uئإءء}وث {uئإ٩٧}{uئإ٨٤}{uئإ٩آ}{uئآئئ}{uئإءإ}ات {uئإؤ٣}{uئإ٨إ}ر{uئإإ٣}{uئإ٨إ}{uئإؤآ}{uئإإإ}{uئإؤئ}{uئإإإ}{uئإ٩ئ}{uئآئئ}{uئآءآ} {uئإؤئ}{uئإءء}واء {uئإ٩ئ}{uئإإ٠}{uئآئئ}{uئإؤأ}{uئإئأ}زا{uئآئإ}{uئإءء} {uئإإ٣}{uئإإ٨}{uئإؤ٤}{uئإءإ}داً أو {uئإإ٣}{uئإآأ}{uئإء٤}{uئإإإ}{uئإ٩١}{uئإ٨إ} {uئإ٩١}{uئإؤأ}{uئإ٨إ}ر{uئإ٩١}{uئإ٨إ}{uئإإ٣}{uئآئئ}{uئإآ٠}ا{uئإ٩١}{uئآئئ}{uئإإ٦} او {uئإء٣}{uئإإ٤}{uئإآإ} ا{uئإئ٧}{uئإؤئ}{uئإؤ٤}{uئإ٨إ} {uئإؤئ}{uئآئئ}{uئإ٩٢}{uئإإإ}{uئآئإ}{uئإؤء} {uئإؤ٣}{uئإئ٢} ا{uئإؤئ}{uئإء٠}{uئإءإ}ذان ا{uئإؤئ}{uئإإ٤}{uئإآأ}{uئإ٨إ}{uئإ٩١}{uئآءآ} {uئإ٩٧}{uئإء٠}{uئإءإ}{uئآئإ}{uئإ٩٢}{uئآئئ}{uئإ٨إ} {uئإ٩١}{uئإ٨إ}{uئإأآ}{uئإ٩٨}{uئإئأ}ل ا{uئإئ٧}{uئإأآ}{uئإآأ}{uئإ٨إ}ب ا{uئإؤئ}{uئإآ٤}{uئإؤأ}{uئإءإ}ي
260 _aCairo :
_bMohamed Farouk Ahmed Abdelsalam ,
_c2015
300 _a180 P. :
_bcharts ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
520 _aThe present study aimed to evaluate the possible pharmacological effects of carbamazepine (CMB) and alpha lipoic acid (ALA) added to an antidiabetic agent, gliclazide (GZ), against experimentally induced diabetic neuropathy in rats. The study was divided into a pilot study and a main study. The pilot study was carried out to determine the time required to develop early diabetic neuropathy in STZ-induced diabetes in male rats. According to the results obtained from the pilot study, the main study was carried out to assess the possible treatment and prophylactic effects of CMB and ALA against the development of diabetic neuropathy after fourteen consecutive days of daily combined treatment with GZ. The assessments were accomplished by: 1- Monitoring behavioral responses to external thermal and mechanical stimuli. 2- Biochemical evaluation for carbohydrate metabolism by determining glucose serum levels and C-peptide, beside inflammatory biomarkers such as TNF alpha serum level and IL-10, oxidative stress biomarkers including serum nitric oxide (NO) level and MDA level, and high affinity insulin receptor (HAIR) and low affinity insulin receptor (LAIR) levels in hippocampus tissue
530 _aIssued also as CD
653 4 _aHippocampus tissue
653 4 _aInflammation
653 4 _aOxidative stress
700 0 _aEzz Eldin S. Eldenshary ,
_eSupervisor
700 0 _aRania M. Abdelsalam ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c56283
_d56283