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008 160509s2015 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.28.M.Sc.2015.Mo.A
100 0 _aMohamed Abdelfattah Mohamed
245 1 0 _aAngiotensin-converting enzyme Insertion/deletion polymorphism In hospitalized infants and children with pneumonia /
_cMohamed Abdelfattah Mohamed ; Supervised Hala Hamdy Haaban , Nihal Mohamed Elrifai , Hanan Elhussieny Elwakel
246 1 5 _aحساب معدل تعدد الأشكال (حذف / إضافة) في الإنزيم المحول للأنجيوتنسين في مرضى الالتهاب الرئوي المقيمين داخل المستشفى
260 _aCairo :
_bMohamed Abdelfattah Mohamed ,
_c2015
300 _a123 P. :
_bcharts ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520 _aIn the present case- control study, detection of Angiotensin Converting Enzyme (ACE) Polymorphism among admitted children suffering from community-acquired pneumonia (CAP) was performed to investigate the associationbetweenACE polymorphismand the risk and outcome of CAP. The study was conducted on 77 children with CAP and 73 healthy age- and sex- matched controls. Cases were subjected to a complete clinical study and investigations were performed: Complete Blood Count (CBC), chest x- ray (CXR), C - reactive protein (CRP), Erythrocytic Sedimentation Rate (ESR) in the first hour, and Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) Polymorphism using polymerase chain reaction (PCR). The study yielded the following results:The present study couldn{u2019}t demonstrate a significant association between different types of ACE genotypes of ACE polymorphism in relation to pneumonia risk(P value >0.05).There was no statistically significant association between different genotypes of ACE polymorphismin pneumonia patients and outcome of pneumonia (oxygen need, ICU admission, need for mechanical ventilation, death & hospital stay more than 1 week) (P value >0.05). The study concludes that ACE polymorphismhas no significant relation to risk & outcome of pediatric pneumonia. Therefore, further studies in this topic should be conducted
530 _aIssued also as CD
653 4 _aACE
653 4 _aPneumonia
653 4 _aPolymorphism
700 0 _aHala Hamdy Shaaban ,
_eSupervisor
700 0 _aHanan Elhussieny Elwakel ,
_eSupervisor
700 0 _aNihal Mohamed Elrifai ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAml
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c56326
_d56326