000			02998cam a2200349 a 4500
003			EG-GiCUC
005			20250223031505.0
008			160510s2015 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2015.Ah.S
100	0		_aAhmed Badr Ali
245	1	0	_aStudy of the clinico-laboratory and ultrasonograpic spectrum of hepatic dysfunction among viral hepatitis (C) positive Egyptian children with sickle cell disease / _cAhmed Badr Ali ; Supervised Rokaya Mohamed Elsayed , Amina Abdelsalam Mohmoud , Marwa Salah Farhan
246	1	5	_aدراسه سوء وظائف الكبد بين الاطفال المصريين المصابين بالتهاب الكبد فيروس (س) و يعانون من انيميا الخلايا المنجليه بدراسه الفحص الاكلينيكى و المعملى مع طيف الاشعه التلفزيونيه لهم
260			_aCairo : _bAhmed Badr Ali , _c2015
300			_a95 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aHepatobiliary involvement in patients with sickle cell disease is multifactorial and ranges from benign hyperbilirubinemia to potentially fatal fulminant hepatic failure. This study aimed to assess the sero prevalence of hepatitis C virus among children with sickle cell disease at a single Egyptian center and to evaluate its impact on the laboratory and ultrasonographic spectrum of hepatic dysfunction among those children. The study included 76 sickle cell disease patients, aged 1 to 38 years (41 males and 35 females).Complete blood picture, liver functions and anti HCV by third generation enzyme immunoassay for anti HCV IgG according to the manufacturer{u2019}s instructions, as well as abdominal ultrasonographic examination were performed for all patients. Mean age of patients was 11.8 years with 68/76 (89.5%) children. Fifty three (69.7%) of the studied cases have received transfusion with mean age at1sttransfusion 2.85 years. Twenty / 76 patients (26.3%) were HCV sero positive. Twelve/20 (60%) had positive HCV RNA testing.Ultrasonography revealed that splenomegaly was the most common finding seen in 18 (23.7%), followed by gall bladder diseases17 (22.3%) and hepatomegaly in 15 (19.7%). HCV positive cases showed a significantly higher frequencies of leg ulcers, thrombotic events, easy bruisebility, jaundice and cholecystectomy when compared to HCV negative group P < 0.05
530			_aIssued also as CD
653		4	_aHepatobiliary
653		4	_aSickle cell disease
653		4	_aUltrasonography
700	0		_aAmina Abdelsalam Mohmoud , _eSupervisor
700	0		_aMarwa Salah Farhan , _eSupervisor
700	0		_aRokaya Mohamed Elsayed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c56350 _d56350