| 000 | 02448cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 160517s2015 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.23.Ph.D.2015.Ah.C | ||
| 100 | 0 | _aAhmad Mahrous Dewidar | |
| 245 | 1 | 0 |
_aCarboplatin/gemcitabine as first line treatment of metastatic triple negative breast cancer / _cAhmad Mahrous Dewidar ; Supervised Mohammad Ahmad Hassan , Mohammad Sayed Abdelkader , Wael Samir Makar |
| 246 | 1 | 5 | _aعلاج سرطان الثدي السلبي الثلاثي المنتشر باستخدام عقاري الجيمسيتابين/كاربوبلاتين كخط علاج أول |
| 260 |
_aCairo : _bAhmad Mahrous Dewidar , _c2015 |
||
| 300 |
_a72 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Oncology (clinical) | ||
| 520 | _aBackground and objectives: Triple-negative breast cancer is regarded as an aggressive disease for which effective targeted therapy is not yet available. Results: Among the 34 included patients , 33 were considered valuable for response as one patient refused to continue treatment after she received the first week of treatment due to grade 3 vomiting, four patients (12.1%) achieved complete response and 20 patients (60.6%) had a partial response giving an overall response rate of 72.7% (95% CI, 60%-84%), one patients(3%) had stable disease > 6 months giving clinical benefit rate(CBR) of 75.7% (25/٣٣). The median duration of response of 6.5 months. while 8 cases progressed in treatment (24.7%), Median progression-free survival, was 6.18 months (95% CI 5.61{u2013}7·30 ) .Overall survival was 12.7month (range2-24, SD: 5.1) . Neutropenia G3 in 3 patients(9%) one of them developed febrile neutropenia ,anemia grade three in 4\33 patients(12%), thrombocytopenia grade 3 in 5 patinets (15%). Conclusions:. This study suggested that The combination was efficacious and well tolerated | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBreast cancer | |
| 653 | 4 | _aMetastatic | |
| 653 | 4 | _aTriple negative | |
| 700 | 0 |
_aMohammad Ahmad Hassan , _eSupervisor |
|
| 700 | 0 |
_aMohammad Sayed Abdelkader , _eSupervisor |
|
| 700 | 0 |
_aWael Samir Makar , _eSupervisor |
|
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSoheir _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c56504 _d56504 |
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