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003 EG-GiCUC
005 20250223031510.0
008 160518s2015 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.12.21.Ph.D.2015.Gh.E
100 0 _aGhada Abdelmonem Ismaiel Zhran
245 1 0 _aEvaluation of potential protective role of different stages of echinostoma liei antigens against schistosoma mansoni in mice /
_cGhada Abdelmonem Ismaiel Zhran ; Supervised Azza Mohamed Elamir , Alyaa Ahmed Farid , Hoda Yakoup
246 1 5 _a{uFEBF}{uFEAA} ا{uئإؤئ}{uئإ٩٢}{uئإإ٠}{uئإإأ}{uئإ٨إ}ر{uئإآ٣}{uئإئ٤}{uئإ٨إ} ا{uئإؤئ}{uئإإ٤}{uئإأأ}{uئإإإ}{uئإئ٣}{uئإإء} فى ا{uئإؤئ}{uئإؤ٤}ئران ا{uئإؤئ}{uئإآأ}{uئإؤ٠}{uئإئ٤}{uئإءإ}{uئإإ٩} Echinostoma liei {uFE97}{uFED8}{uFEF4}{uFEF4}{uFEE2} دو ا{uئإؤئ}{uئإء٤}{uئإإ٤}{uئإ٨إ}{uئإئ٣}{uئإإء} ا{uئإؤئ}{uئإؤ٤}{uئإأأ}{uئإ٨إ}{uئإؤئ}{uئإإء} {uئإئ٧}{uئإإ٧}{uئإ٩٨}{uئإئ٤}{uئإء٠}{uئإئ٤}{uئإإ٨}{uئإ٨إ}ت ا{uئإؤئ}{uئإإ٤}{uئإءإ}ا{uئإء٣}{uئإؤإ} ا{uئإؤئ}{uئإإ٤}{uئإء٨}{uئإ٩٨}{uئإإ٠}{uئإؤ٤}{uئإإء} {uئإإ٣}{uئإإ٦}
260 _aCairo :
_bGhada Abdelmonem Ismaiel Zhran ,
_c2015
300 _a100 Leaves :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology
520 _aThe effect of immunization protocol against S. mansoni infection with purified antigens from E. liei on resistance to S. mansoni infection and associated immunoparasitological changes in murine experimental model was studied. High significant reduction in worm burden, hepatic and intestinal tissue egg loads were observed on comparing the immunized groups with the infected control group (P > 0.001). The results showed an alteration in the Egg deposition, reduction in MGN, MGD amount of hepatic fibrosis, interference with granuloma maturation and cytokine secretion level. Results revealed that immunization with E. liei worm antigens stimulated IgG1, IgG2 and IgG4 secretion more than any other type of antigens. On the other hand, E. liei rediae antigens were more effective than other types in stimulating IgM secretion when compared to infected control group. In conclusion, our findings showed that multiple intraperitoneal adminestration of purified E. liei antigen induce highly significant reduction in worm burden, hepatic and intestinal tissue egg loads and granuloma size 8 weeks post infection
530 _aIssued also as CD
653 4 _aELISA
653 4 _aS. haematobium
653 4 _aSchistosomiasis
700 0 _aAlyaa Ahmed Farid ,
_eSupervisor
700 0 _aAzza Mohamed Elamir ,
_eSupervisor
700 0 _aHoda Yakoup ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c56523
_d56523