000			03257cam a2200349 a 4500
003			EG-GiCUC
005			20250223031512.0
008			160523s2015 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.09.Ph.D.2015.Re.P
100	0		_aReham Abdelrahman Mohammad Elnaggar
245	1	0	_aPossible modification by certain natural products of effects of anti - diabetic drugs in metabolic syndrome in rats / _cReham Abdelrahman Mohammad Elnaggar ; Supervised Ezz Eldin Eldenshary , Effat Haroon , Olfat Shaker
246	1	5	_aإمكانية تغيير فاعلية بعض الأدوية المضادة لمرض السكر باستخدام مواد طبيعية فى الجرذان المصابة بالمتلازمة الأيضية
260			_aCairo : _bReham Abdelrahman Mohammad Elnaggar , _c2015
300			_a252 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
520			_aHigh intake of dietary fructose is accused for responsibility for the development of the metabolic syndrome (MS). This work aimed to observe the beneficial effect of sitagliptin (Sita), pioglitazone (Pio), alpha lipoic acid (ALA), taurine (Tau) or their combination on fructose-induced MS. Ten groups of rats (n = 12) were fed on fructose enriched diet (FED) for 14 weeks followed by single i.p. injection of streptozotocin (STZ). One served as FED control while the remaining groups received sitagliptin (10 mg / kg. p.o.), pioglitazone (10 mg / kg. p.o.), Ü- lipoic acid (100 mg / kg .p.o.), Taurine (100 mg / kg. p.o.) or their combination, respectively, for the last 4 weeks. A fifth group was fed with on normal diet (normal control). At the end of the study body weight and systolic blood pressure (SBP) were measured, blood samples were collected for estimation of fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance (IR), insulin sensitivity (IS), Ý- cell functions (BCF), triglycerides (TG), total cholesterol (TC), high density lipoproteins cholesterol (HDL - C), low density lipoproteins cholesterol (LDL - C), malondialdehyde (MDA) and uric acid as well as superoxide dismutase (SOD) and glutathione - S - transferase (GST) activities. Induction of MS resulted in significant increases in SBP, FBG, FINS, IR, TG, TC, LDL - C, MDA and uric acid. Meanwhile it resulted in a significant decrease in IS, BCF as well as SOD and GST activities. Treatment of rats with sitagliptin resulted in significant reduction in SBP, hyperglycemia, IR, TG, T. cholesterol, LDL - C, MDA and uric acid levels, as well as improvement in BCF and IS. Similarly, treatment of insulin resistant rats with pioglitazone showed similar results in addition to improvement in serum SOD activity
530			_aIssued also as CD
653		4	_aAlpha lipoic acid
653		4	_aSitagliptin
653		4	_aTaurine
700	0		_aEffat Haroon , _eSupervisor
700	0		_aEzz Eldin Eldenshary , _eSupervisor
700	0		_aOlfat Shaker , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c56588 _d56588