000			02242cam a2200313 a 4500
003			EG-GiCUC
008			160524s2015 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.05.M.Sc.2015.Ah.S
100	0		_aAhmed Abbass Mohamed Abdelrahman
245	1	0	_aSynthesis and biological evaluation of certain pyrazole derivatives / _cAhmed Abbass Mohamed Abdelrahman ; Supervised Fatma Abdelfattah Ragab , Yassin Mohammed Nissan Soliman
246	1	5	_aتشييد و تقييم بيولوجى لبعض مركبات البيرازول
260			_aCairo : _bAhmed Abbass Mohamed Abdelrahman , _c2015
300			_a284 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry
520			_aThe present investigation deals with the semi-synthesis of certain 1,3,4- trisubstituted pyrazole derivatives derived from the natural furochromone khellin, to be screened for their in vivo anti-inflammatory activity and ulcerogenic liability hoping to obtain anti-inflammatory agents with high potency and lower side effects. Furthermore, PGE₂ and TNFÜ immunoassay were carried out to determine the percentage inhibition of these factors by the most active tested compounds. Docking study was conducted for the tested compounds on the active site of COX-2 enzyme to study the binding mode in the active site of the enzyme.The thesis consists of the following parts: 1.Introduction: In this section, literature review about the various biological and pharmacological activities especially the anti-inflammatory activity of pyrazole, pyrazoline, benzofuran and chalcone derivatives was presented. Also, different reported methods for the preparation of both pyrazole and pyrazoline nuclei were described
530			_aIssued also as CD
653		4	_aAnti-inflammatory activity of pyrazole
653		4	_aCertain pyrazole derivatives
653		4	_aPyrazoles
700	0		_aFatma Abdelfattah Ragab , _eSupervisor
700	0		_aYassin Mohammed Nissan Soliman , _eSupervisor
905			_aAml _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c56613 _d56613