| 000 | 03127cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223031514.0 | ||
| 008 | 160525s2015 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.30.M.Sc.2015.Ne.S | ||
| 100 | 0 | _aNeamat Mahmoud Abdelgilil | |
| 245 | 1 | 2 |
_aA study on the possible role of insulin IGF 1 axis in pre neoplastic inflammation induced in female rats / _cNeamat Mahmoud Abdelgilil ; Supervised Magda Mahmoud Elhamzawy , Omnia Mohamed Abdelmaksod , Heba Samy Ibrahim |
| 246 | 1 | 5 | _aدراسة دور الانسولين و عامل النمو المعتمد على الانسولين فى الالتهابات المؤدية الى رحلة ما قبل السرطان فى اناث الفئران |
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_aCairo : _bNeamat Mahmoud Abdelgilil , _c2015 |
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| 300 |
_a251 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology | ||
| 520 | _aThe role of insulin and its status are key components in metabolic syndrome. Impressive body of epidemiological data collected over the past decade indicates that a disturbing link may connect the insulin status, to a pre-neoplastic state which may fortell an additional danger: cancer. This evidence also includes studies that examined in particular, the risk of colon cancer or adenoma in relation to some significant determinants of metabolic syndrome related to the insulin IGF 1 axis. Thus, the present study aimed to further explore the possible role of insulin, IGF-1 axis in modulating the pathogenic events related to the low grade chronic pre-neoplastic inflammation induced experimentally in the colon of a diabetic female rat model. To achieve this aim, two experimental diabetic models were induced. The first experimental model was applied to a group of female rats to induce hyperinsulinemia (T2DM) by keeping them on a diet of high glycemic value ad lipidum. The second was induced on a second group of animals to induce a state of hypoinsulinemia (T1DM) by giving them a single dose of streptozotocin. Study groups included: a control group representing the vehicle treated rats (Group I) and two main experimental groups: T2DM (Group II) and T1DM (Group III). All animals were left for a study period of 8 weeks. Four weeks before the termination of the study period, the animals of the three groups were further divided into 2 subgroups: the A subgroups (IA, IIA, IIIA) were slowly infused with a single dose of saline into the distal colon, the B subgroups (IB, IIB, IIIB) were subjected to a single intracolonic dose infusion of 4% acetic acid solution | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCancer | |
| 653 | 4 | _aDiabetes | |
| 653 | 4 | _aInsulin IGF 1 | |
| 700 | 0 |
_aHeba Samy Ibrahim , _eSupervisor |
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| 700 | 0 |
_aMagda Mahmoud Elhamzawy , _eSupervisor |
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| 700 | 0 |
_aOmnia Mohamed Abdelmaksod , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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_aSamia _eCataloger |
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_2ddc _cTH |
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_c56635 _d56635 |
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