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| 003 | EG-GiCUC | ||
| 005 | 20250223031527.0 | ||
| 008 | 170103s2016 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.09.M.Sc.2016.Ah.S | ||
| 100 | 0 | _aAhmed Mohamed Eldesoky Youssef | |
| 245 | 1 | 2 |
_aA study of the possible neuroprotective effects of simvastatin and curcumin in l-methionine-induced vascular dementia in rats / _cAhmed Mohamed El Desoky Youssef ; Supervised Hala Fahmy Zaki , Azza Sayed Awad , May A. Galal |
| 246 | 1 | 5 | _aدراسة لتأثيرات الوقاية العصبية المحتملة لكل من سيمفاستاتين و الكركمين في الخرف الوعائي الذي يسببه ل-ميثيونين في الجرذان |
| 260 |
_aCairo : _bAhmed Mohamed Eldesoky Youssef , _c2016 |
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| 300 |
_a212 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aVascular dementia (VaD) is a degenerative cerebrovascular disorder that leads to progressive decline in cognitive abilities and memory. Several reports demonstrated that oxidative stress and endothelial dysfunction are principal pathogenic factors in VaD. The present study was constructed to determine the possible neuroprotective effects of simvastatin and curcumin in comparison with cilostazol in VaD induced by l-methionine in rats. Male Wistar rats were divided into five groups. Group I (control group), group II received l-methionine (1.7g/kg, p.o.) for 32 days. The remaining three groups received simvastatin (50 mg/kg, p.o.), curcumin (300mg/kg, p.o.) and cilostazol (100 mg/kg, p.o.), respectively for 32 days after induction of VaD by l-methionine. Subsequently, rats were tested for cognitive performance using Morris water maze test then sacrificed for biochemical and histopathological assays. L-methionine induced VaD reflected by alterations in rats' behavior as well as the estimated neurotransmitters, acetylcholinesterase activity, as well as, increased brain oxidative stress and inflammation parallel to histopathological changes in brain tissue. Treatment of rats with simvastatin or curcumin ameliorated l-methionine-induced behavioral, neurochemical and histological changes in a manner comparable to cilostazol. Simvastatin or curcumin may be regarded as a potential therapeutic strategy for the treatment of VaD | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aL-methionine | |
| 653 | 4 | _aSimvastatin | |
| 653 | 4 | _aVascular dementia | |
| 700 | 0 |
_aAzza Sayed Awad , _eSupervisor |
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| 700 | 0 |
_aHala Fahmy Zaki , _eSupervisor |
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| 700 | 0 |
_aMay Ahmed Galal , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aEnas _eCataloger |
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_aNazla _eRevisor |
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_2ddc _cTH |
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_c57087 _d57087 |
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