000			03154cam a2200349 a 4500
003			EG-GiCUC
005			20250223031528.0
008			160712s2016 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.30.M.Sc.2016.He.C
100	0		_aHeba Ahmed Hashem Muhammad
245	1	2	_aA comparative Study of the possible cardioprotective effects of Erythropoietin in diabetic and uremic cardiomyopathy in rats / _cHeba Ahmed Hashem Muhammad ; Supervised Hania Ibrahim Ammar , Muhammad Ali Eashra , Ayman Saieed Soliman
246	1	5	_aدراسة مقارنة للتأثير المحتمل للإرثروبويتين في حماية القلب عند مريض اعتلال عضلة القلب الناتج عن السكر و الفشل الكلوي عند الفئران
260			_aCairo : _bHeba Ahmed Hashem Muhammad , _c2016
300			_a227 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology
520			_aCardiomyopathy is a common chronic complication associated with diabetes and chronic kidney disease. Erythropoietin (EPO) was reported as a broad spectrum cardioprotective agent. We aim to compare between the effect of long term administration of EPO in prevention or delaying development of diabetic or uremic cardiomyopathy. Diabetes was induced by intraperitoneal (IP) injection of 65mg/kg STZ. Uremia was induced by 5/6 subtotal nephrectomy. EPO treated diabetic and uremic groups were injected with 1000 IU/kg of EPO (IP) twice weekly till the end of the study. At the 12th and the 16th for diabetic and uremic groups respectively heart tissues were collected for pathological examination. Result: compared to sham and EPO treated nephrectomy group the untreated nephrectomy group showed significant decrease in EF% & FS% by the 12th week with more decrease by the 16th week of the study, while EPO treated nephrectomy group show significant decrease in EF% & FS% only by the 16th week compared to sham group but still significantly higher than values of untreated nephrectomy group at the same time interval. Both EPO treated and untreated diabetic groups showed significant decrease in EF% & FS% by the 4th week with further more decrease up to the 12th week of the study. Pathological examination for hearts from EPO treated nephrectomy show significant increase in capillary numbering and decrease in area % of fibrosis compared to untreated nephrectomy and sham group.Conclusion: the beneficial role of EPO as a cardioprotective is differentially activated or inactivated according to the underlying cause of cardiomyopathy
530			_aIssued also as CD
653		4	_aDiabetic cardiomyopathy
653		4	_aErythropoietin
653		4	_aUremic cardiomyopathy
700	0		_aAyman Saieed Soliman , _eSupervisor
700	0		_aHania Ibrahim Ammar , _eSupervisor
700	0		_aMuhammad Ali Eashra , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c57151 _d57151